|
|
|
| Research progress of cell death in radiation protection and radiosensitization |
| TIAN Maoye, NIE Hongmei, LIU Ya, LIU Wei, LONG Wei |
| Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192 China |
|
|
|
|
Abstract The rapid advances in technology and medicine have greatly facilitated the application of ionizing radiation. Clinically, radiotherapy is one of the major treatments for malignant tumors. However, besides killing tumor cells, ionizing radiation inevitably leads to radiation damage and even death of normal cells. How ionizing radiation causes cell death and the forms of cell death have always been important research topics in this field. Recently, several forms of cell death induced by irradiation have been discovered. Apart from apoptosis, pyroptosis, necroptosis, ferroptosis, autophagic cell death, and methuosis have gradually become research hotspots, and provide new targets for the development of radioprotective drugs and radiosensitizers. In this review, we summarize various forms of ionizing radiation-induced cell death and related molecular mechanisms. We also introduce the latest progress in radiation protection and radiosensitization based on these cell death mechanisms. This review will provide a reference for the research and development of radioprotective drugs and radiosensitizers in the future.
|
|
Received: 19 September 2022
|
|
|
|
|
|
[1] Averbeck D, Rodriguez-Lafrasse C. Role of mitochondria in radiation responses: epigenetic, metabolic, and signaling impacts[J]. Int J Mol Sci, 2021, 22(20): 11047. DOI: 10.3390/ijms222011047
[2] Adjemian S, Oltean T, Martens S, et al. Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death[J]. Cell Death Dis, 2020, 11(11): 1003. DOI: 10.1038/s41419-020-03209-y
[3] 魏新锋, 王蕊, 衣峻萱, 等. 低剂量辐射生物效应的研究进展[J]. 中国辐射卫生,2022,31(1):113-118,128. DOI: 10.13491/j.issn.1004-714X.2022.01.020
Wei XF, Wang R, Yi JX, et al. Research progress in biological effects of low-dose radiation[J]. Chin J Radiol Health, 2022, 31(1): 113-118,128. DOI: 10.13491/j.issn.1004-714X.2022.01.020
[4] Cao XB, Wen PB, Fu YF, et al. Radiation induces apoptosis primarily through the intrinsic pathway in mammalian cells[J]. Cell Signal, 2019, 62: 109337. DOI: 10.1016/j.cellsig.2019.06.002
[5] Marek J, Tichy A, Havelek R, et al. A novel class of small molecule inhibitors with radioprotective properties[J]. Eur J Med Chem, 2020, 187: 111606. DOI: 10.1016/j.ejmech.2019.111606
[6] Bing SJ, Kim MJ, Ahn G, et al. Acidic polysaccharide of Panax ginseng regulates the mitochondria/caspase-dependent apoptotic pathway in radiation-induced damage to the jejunum in mice[J]. Acta Histochem, 2014, 116(3): 514-521. DOI: 10.1016/j.acthis.2013.11.012
[7] Cheng Y, Ren X, Gowda ASP, et al. Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress[J]. Cell Death Dis, 2013, 4(7): e731. DOI: 10.1038/cddis.2013.254
[8] Cao K, Chen YY, Zhao SY, et al. Sirt3 promoted DNA damage repair and radioresistance through ATM-Chk2 in non-small cell lung cancer cells[J]. J Cancer, 2021, 12(18): 5464-5472. DOI: 10.7150/jca.53173
[9] Zychlinsky A, Prevost MC, Sansonetti PJ. Shigella flexneri induces apoptosis in infected macrophages[J]. Nature, 1992, 358(6382): 167-169. DOI: 10.1038/358167a0
[10] Xiang HL, Zhu F, Xu ZF, et al. Role of inflammasomes in kidney diseases via both canonical and non-canonical pathways[J]. Front Cell Dev Biol, 2020, 8: 106. DOI: 10.3389/fcell.2020.00106
[11] Zhou ZW, He HB, Wang K, et al. Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells[J]. Science, 2020, 368(6494): eaaz7548. DOI: 10.1126/science.aaz7548
[12] Wang YP, Gao WQ, Shi XY, et al. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin[J]. Nature, 2017, 547(7661): 99-103. DOI: 10.1038/nature22393
[13] Hu B, Jin CC, Li HB, et al. The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury[J]. Science, 2016, 354(6313): 765-768. DOI: 10.1126/science.aaf7532
[14] Smith AO, Ju W, Adzraku SY, et al. Gamma radiation induce inflammasome signaling and pyroptosis in microvascular endothelial cells[J]. J Inflamm Res, 2021, 14: 3277-3288. DOI: 10.2147/JIR.S318812
[15] Li YH, He Q, Chen YZ, et al. p-Coumaric acid ameliorates ionizing radiation-induced intestinal injury through modulation of oxidative stress and pyroptosis[J]. Life Sci, 2021, 278: 119546. DOI: 10.1016/j.lfs.2021.119546
[16] Cao W, Chen GD, Wu LJ, et al. Ionizing radiation triggers the antitumor immunity by inducing gasdermin E-mediated pyroptosis in tumor cells[J]. Int J Radiat Oncol Biol Phys, 2023, 115(2): 440-452. DOI: 10.1016/j.ijrobp.2022.07.1841
[17] Tan G, Lin CJ, Huang CY, et al. Radiosensitivity of colorectal cancer and radiation-induced gut damages are regulated by gasdermin E[J]. Cancer Lett, 2022, 529: 1-10. DOI: 10.1016/j.canlet.2021.12.034
[18] Murphy JM, Czabotar PE, Hildebrand JM, et al. The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism[J]. Immunity, 2013, 39(3): 443-453. DOI: 10.1016/j.immuni.2013.06.018
[19] Fritsch M, Günther SD, Schwarzer R, et al. Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis[J]. Nature, 2019, 575(7784): 683-687. DOI: 10.1038/s41586-019-1770-6
[20] Das A, McDonald DG, Dixon-Mah YN, et al. RIP1 and RIP3 complex regulates radiation-induced programmed necrosis in glioblastoma[J]. Tumor Biol, 2016, 37(6): 7525-7534. DOI: 10.1007/s13277-015-4621-6
[21] Xu YQ, Tu WZ, Sun D, et al. Nrf2 alleviates radiation-induced rectal injury by inhibiting of necroptosis[J]. Biochem Biophys Res Commun, 2021, 554: 49-55. DOI: 10.1016/j.bbrc.2021.03.004
[22] Ding Y, Ma L, He LM, et al. A strategy for attenuation of acute radiation-induced lung injury using crocetin from gardenia fruit[J]. Biomed Pharmacother, 2022, 149: 112899. DOI: 10.1016/j.biopha.2022.112899
[23] Uzunparmak B, Gao M, Lindemann A, et al. Caspase-8 loss radiosensitizes head and neck squamous cell carcinoma to SMAC mimetic-induced necroptosis[J]. JCI Insight, 2020, 5(23): e139837. DOI: 10.1172/jci.insight.139837
[24] Wang YW, Zhao MH, He SJ, et al. Necroptosis regulates tumor repopulation after radiotherapy via RIP1/RIP3/MLKL/JNK/IL8 pathway[J]. J Exp Clin Cancer Res, 2019, 38(1): 461. DOI: 10.1186/s13046-019-1423-5
[25] Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death[J]. Cell, 2012, 149(5): 1060-1072. DOI: 10.1016/j.cell.2012.03.042
[26] Ye LF, Chaudhary KR, Zandkarimi F, et al. Radiation-induced lipid peroxidation triggers ferroptosis and synergizes with ferroptosis inducers[J]. ACS Chem Biol, 2020, 15(2): 469-484. DOI: 10.1021/acschembio.9b00939
[27] Zhang X, Liu H, Xing X, et al. Ionizing radiation induces ferroptosis in splenic lymphocytes of mice[J]. Int J Radiat Res, 2021, 19(1): 99-111. DOI: 10.29252/ijrr.19.1.99
[28] Almahi WA, Yu KN, Mohammed F, et al. Hemin enhances radiosensitivity of lung cancer cells through ferroptosis[J]. Exp Cell Res, 2022, 410(1): 112946. DOI: 10.1016/j.yexcr.2021.112946
[29] Lei G, Zhang YL, Hong T, et al. Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity[J]. Oncogene, 2021, 40(20): 3533-3547. DOI: 10.1038/s41388-021-01790-w
[30] Feng L, Zhao KK, Sun LC, et al. SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis[J]. J Transl Med, 2021, 19(1): 367. DOI: 10.1186/s12967-021-03042-7
[31] Chen L, Lin GX, Chen KH, et al. VEGF knockdown enhances radiosensitivity of nasopharyngeal carcinoma by inhibiting autophagy through the activation of mTOR pathway[J]. Sci Rep, 2020, 10(1): 16328. DOI: 10.1038/s41598-020-73310-x
[32] Sun YC, Chen KH, Lin GX, et al. Silencing c-Jun inhibits autophagy and abrogates radioresistance in nasopharyngeal carcinoma by activating the PI3K/AKT/mTOR pathway[J]. Ann Transl Med, 2021, 9(13): 1085. DOI: 10.21037/atm-21-2563
[33] Chen CX, Wang KZ, Wang Q, et al. LncRNA HULC mediates radioresistance via autophagy in prostate cancer cells[J]. Braz J Med Biol Res, 2018, 51(6): e7080. DOI: 10.1590/1414-431x20187080
[34] Li Y, Liu F, Wang Y, et al. Rapamycin-induced autophagy sensitizes A549 cells to radiation associated with DNA damage repair inhibition[J]. Thorac Cancer, 2016, 7(4): 379-386. DOI: 10.1111/1759-7714.12332
[35] Overmeyer JH, Kaul A, Johnson EE, et al. Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis[J]. Mol Cancer Res, 2008, 6(6): 965-977. DOI: 10.1158/1541-7786.MCR-07-2036
[36] Bhanot H, Young AM, Overmeyer JH, et al. Induction of nonapoptotic cell death by activated Ras requires inverse regulation of Rac1 and Arf6[J]. Mol Cancer Res, 2010, 8(10): 1358-1374. DOI: 10.1158/1541-7786.MCR-10-0090
[37] Tsvetkov P, Coy S, Petrova B, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins[J]. Science, 2022, 375(6586): 1254-1261. DOI: 10.1126/science.abf0529
|
|
|
|
