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| Effects of microwave radiation on learning and memory and neurotransmitters in the hippocampus |
| DU Dan1,2, SHANG Mengjuan2, LIN Jiajin2, MIAO Xia2, YAN Yuming2, XU Shenglong2, SUN Na1, LI Jing2 |
1. School of Public Health, Shaanxi University of Chinese Medicine, Xianyang 712000 China;
2. Department of Radiation Protective Medicine, Air Force Military University, Xi’an 710032 China |
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Abstract The central nervous system is one of the most sensitive targets of microwave radiation. Microwave radiation can affect spatial learning and memory and neural information transmission. The effects of microwave radiation on neurotransmitters in the hippocampus and the underlying mechanisms are still unclear. This paper reviews the effects of microwave radiation on learning/memory and neurotransmitters as well as the mechanisms of action on neurotransmitters. This paper aims to provide a scientific basis for future research in this area.
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Received: 22 September 2022
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[1] Foerster M, Thielens A, Joseph W, et al. A prospective cohort study of Adolescents’ memory performance and individual brain dose of microwave radiation from wireless communication[J]. Environ Health Perspect, 2018, 126(7): 077007. DOI: 10.1289/EHP2427
[2] 王篪, 何俊, 张丽. 长期微波暴露健康危害的研究进展[J]. 中国辐射卫生,2022,31(5):639-644. DOI: 10.13491/j.issn.1004-714X.2022.05.023
Wang C, He J, Zhang L. Recent advances in health hazards of long-term exposure to microwave radiation[J]. Chin J Radiol Health, 2022, 31(5): 639-644. DOI: 10.13491/j.issn.1004-714X.2022.05.023
[3] Megha K, Deshmukh PS, Ravi AK, et al. Effect of Low-intensity microwave radiation on monoamine neurotransmitters and their key regulating enzymes in Rat Brain[J]. Cell Biochem Biophys, 2015, 73(1): 93-100. DOI: 10.1007/s12013-015-0576-x
[4] 丁胜元, 罗荣敬. 滋阴补肾、养心安神法对老年阴虚大鼠模型学习记忆的影响[J]. 解剖学研究,2002,24(1):69
Ding SY, Luo RJ. Effects of nourishing Yin, tonifying the kidney and nourishing the heart and calming the mind on learning and memory in an aged rat model of Yin deficiency[J]. Anat Res, 2002, 24(1): 69
[5] Broom KA, Findlay R, Addison DS, et al. Early-life exposure to pulsed LTE radiofrequency fields causes persistent changes in activity and behavior in C57BL/6?J Mice[J]. Bioelectromagnetics, 2019, 40(7): 498-511. DOI: 10.1002/bem.22217
[6] Varghese R, Majumdar A, Kumar G, et al. Rats exposed to 2.45GHz of non-ionizing radiation exhibit behavioral changes with increased brain expression of apoptotic caspase 3[J]. Pathophysiology, 2018, 25(1): 19-30. DOI: 10.1016/j.pathophys.2017.11.001
[7] 任可, 姚传福, 孙柳, 等. 2.8 GHz微波辐射对大鼠空间工作记忆和识别记忆的影响及其结构基础[J]. 中国体视学与图像分析,2022,27(1):62-73. DOI: 10.13505/j.1007-1482.2022.27.01.009
Ren K, Yao CF, Sun L, et al. Effects of 2.8 GHz microwave on spatial working memory and recognition memory in rats and its structural basis[J]. Chin J Stereol Image Anal, 2022, 27(1): 62-73. DOI: 10.13505/j.1007-1482.2022.27.01.009
[8] 王楠, 吕士杰. 微波辐射致小鼠学习记忆损伤作用[J]. 吉林医药学院学报,2019,40(5):321-323. DOI: 10.13845/j.cnki.issn1673-2995.2019.05.001
Wang N, Lü SJ. Effect of microwave radiation on learning and memory damage in mice[J]. J Jilin Med Univ, 2019, 40(5): 321-323. DOI: 10.13845/j.cnki.issn1673-2995.2019.05.001
[9] Sharma A, Kesari KK, Saxena VK, et al. Ten gigahertz microwave radiation impairs spatial memory, enzymes activity, and histopathology of developing mice brain[J]. Mol Cell Biochem, 2017, 435(1/2): 1-13. DOI: 10.1007/s11010-017-3051-8
[10] Deshmukh PS, Megha K, Nasare N, et al. Effect of low level subchronic microwave radiation on rat brain[J]. Biomed Environ Sci, 2016, 29(12): 858-867. DOI: 10.3967/bes2016.115
[11] Zhu RQ, Wang H, Xu XP, et al. Effects of 1.5 and 4.3 GHz microwave radiation on cognitive function and hippocampal tissue structure in Wistar rats[J]. Sci Rep, 2021, 11(1): 10061. DOI: 10.1038/s41598-021-89348-4
[12] Tan SZ, Wang H, Xu XP, et al. Acute effects of 2.856 GHz and 1.5 GHz microwaves on spatial memory abilities and CREB-related pathways[J]. Sci Rep, 2021, 11(1): 12348. DOI: 10.1038/s41598-021-91622-4
[13] Belpomme D, Hardell L, Belyaev I, et al. Thermal and non-thermal health effects of low intensity non-ionizing radiation: an international perspective[J]. Environ Pollut, 2018, 242: 643-658. DOI: 10.1016/j.envpol.2018.07.019
[14] Hu CC, Zuo HY, Li Y. Effects of radiofrequency electromagnetic radiation on neurotransmitters in the brain[J]. Front Public Health, 2021, 9: 691880. DOI: 10.3389/fpubh.2021.691880
[15] 李佳琪, 高丽, 周玉枝, 等. 衰老性学习记忆减退相关的脑内单胺类神经递质研究进展[J]. 药学学报,2017,52(11):1639-1646. DOI: 10.16438/j.0513-4870.2017-0471
Li JQ, Gao L, Zhou YZ, et al. Research advances in brain monoamine neurotransmitters in the aging-associated memory decline[J]. Acta Pharm Sin, 2017, 52(11): 1639-1646. DOI: 10.16438/j.0513-4870.2017-0471
[16] Comelekoglu U, Aktas S, Demirbag B, et al. Effect of low-level 1800?MHz radiofrequency radiation on the rat sciatic nerve and the protective role of paricalcitol[J]. Bioelectromagnetics, 2018, 39(8): 631-643. DOI: 10.1002/bem.22149
[17] Eris AH, Kiziltan HS, Meral I, et al. Effect of Short-term 900 MHz low level electromagnetic radiation exposure on blood serotonin and glutamate levels[J]. Bratisl Med J, 2015, 116(2): 101-103. DOI: 10.4149/bll_2015_019
[18] Zhao L, Peng RY, Wang SM, et al. Relationship between cognition function and hippocampus structure after long-term microwave exposure[J]. Biomed Environ Sci, 2012, 25(2): 182-188. DOI: 10.3967/0895-3988.2012.02.009
[19] Ramos D, Reche-Junior A, Brandão JDP, et al. Unreliability of EDTA samples for measuring bioamine neurotransmitter levels in cats[J]. J Feline Med Surg, 2021, 23(2): 190-193. DOI: 10.1177/1098612X20924916
[20] Birthelmer A, Stemmelin J, Jackisch R, et al. Presynaptic modulation of acetylcholine, noradrenaline, and serotonin release in the hippocampus of aged rats with various levels of memory impairments[J]. Brain Res Bull, 2003, 60(3): 283-296. DOI: 10.1016/s0361-9230(3)00042-x
[21] 高蒙, 彭怀禹, 王向晖, 等. 长期1.8 GHz电磁辐射对大鼠学习认知能力的影响[J]. 辐射研究与辐射工艺学报,2021,39(4):19-25. DOI: 10.11889/j.1000-3436.2021.rrj.39.040301
Gao M, Peng HY, Wang XH, et al. Effect of long-term 1.8 GHz combined electromagnetic radiation on the learning and cognitive ability of rats[J]. J Radiat Res Radiat Process, 2021, 39(4): 19-25. DOI: 10.11889/j.1000-3436.2021.rrj.39.040301
[22] 杨静涵, 张丹参, 景永帅. 氨基酸类神经递质对神经系统疾病的影响及可能机制[J]. 中国药理学与毒理学杂志,2021,35(9):642
Yang JH, Zhang DS, Jing YS. Effects of amino acid neurotransmitters on neurological disorders and possible mechanisms[J]. Chin J Pharmacol Toxicol, 2021, 35(9): 642
[23] 张俊平. 1.8 GHz射频辐射对小鼠情绪和学习记忆的影响及机制探讨[D]. 西安: 中国人民解放军空军军医大学, 2018.
Zhang JP. Effects of 1.8 GHz radiofrequency radiation on the emotional behavior and learning and memory in mice[D]. Xi’an: Air Force Medical University, 2018.
[24] Zhang Y, Chu JMT, Wong GTC. Cerebral glutamate regulation and receptor changes in perioperative neuroinflammation and cognitive dysfunction[J]. Biomolecules, 2022, 12(4): 597. DOI: 10.3390/biom12040597
[25] Ahmed NA, Radwan NM, Ezz HSA, et al. The chronic effect of pulsed 1800 MHz electromagnetic radiation on amino acid neurotransmitters in three different areas of juvenile and young adult rat brain[J]. Toxicol Ind Health, 2018, 34(12): 860-872. DOI: 10.1177/0748233718798975
[26] Zhang JP, Zhang KY, Guo L, et al. Effects of 1.8 GHz radiofrequency fields on the emotional behavior and spatial memory of adolescent mice[J]. Int J Environ Res Public Health, 2017, 14(11): 1344. DOI: 10.3390/ijerph14111344
[27] Wang LF, Tian DW, Li HJ, et al. Identification of a novel rat NR2B subunit gene promoter region variant and its association with microwave-induced neuron impairment[J]. Mol Neurobiol, 2016, 53(4): 2100-2111. DOI: 10.1007/s12035-015-9169-3
[28] 班婷婷. 乐果对大鼠中枢抑制性氨基酸神经递质系统的影响[D]. 上海: 复旦大学, 2007. DOI: 10.7666/d.y1169145.
Ban TT. Effect of lego on the central inhibitory amino acid neurotransmitter system in rats[D]. Shanghai: Fudan University, 2017. DOI: 10.7666/d.y1169145.
[29] Kasten CR, Boehm II SL. Identifying the role of pre-and postsynaptic GABAB receptors in behavior[J]. Neurosci Biobehav Rev, 2015, 57: 70-87. DOI: 10.1016/j.neubiorev.2015.08.007
[30] 徐方剑, 王逸文, 陆寒烨, 等. 低功率密度微波辐射对小鼠学习记忆的影响[J]. 环境与职业医学,2017,34(1):76-78. DOI: 10.13213/j.cnki.jeom.2017.16325
Xu FJ, Wang YW, Lu HY, et al. Effects of low power density microwave radiation on learning and memory in mice[J]. J Environ Occup Med, 2017, 34(1): 76-78. DOI: 10.13213/j.cnki.jeom.2017.16325
[31] Qiao SM, Peng RY, Yan HT, et al. Reduction of phosphorylated synapsin I (Ser-553) leads to spatial memory impairment by attenuating GABA release after microwave exposure in Wistar rats[J]. PLoS One, 2014, 9(4): e95503. DOI: 10.1371/journal.pone.0095503
[32] Gökçek-Saraç Ç, Akçay G, Karakurt S, et al. Possible effects of different doses of 2.1 GHz electromagnetic radiation on learning, and hippocampal levels of cholinergic biomarkers in Wistar rats[J]. Electromagn Biol Med, 2021, 40(1): 179-190. DOI: 10.1080/15368378.2020.1851251
[33] Sharma S, Shukla S. Effect of electromagnetic radiation on redox status, acetylcholine esterase activity and cellular damage contributing to the diminution of the brain working memory in rats[J]. J Chem Neuroanat, 2020, 106: 101784. DOI: 10.1016/j.jchemneu.2020.101784
[34] Gupta SK, Mesharam MK, Krishnamurthy S. Electromagnetic radiation 2450 MHz exposure causes cognition deficit with mitochondrial dysfunction and activation of intrinsic pathway of apoptosis in rats[J]. J Biosci, 2018, 43(2): 263-276. DOI: 10.1007/s12038-018-9744-7
[35] 左红艳, 崔亮, 刘肖, 等. 微波辐射对大鼠海马组织乙酰胆碱代谢及其受体表达的影响[J]. 中国体视学与图像分析,2020,25(1):18-24. DOI: 10.13505/j.1007-1482.2020.25.01.003
Zuo HY, Cui L, Liu X, et al. The effects of microwave radiation on the expression of acetylcholine receptors and acetylcholine metabolism in rat hippocampus[J]. Chin J Stereol Image Anal, 2020, 25(1): 18-24. DOI: 10.13505/j.1007-1482.2020.25.01.003
[36] Terenius L. From opiate pharmacology to opioid peptide physiology[J]. Ups J Med Sci, 2000, 105(1): 1-15. DOI: 10.1517/03009734000000043
[37] Alescio-Lautier B, Soumireu-Mourat B. Role of vasopressin in learning and memory in the hippocampus[J]. Prog Brain Res, 1999, 119: 501-521. DOI: 10.1016/s0079-6123(08)61590-3
[38] Lai H, Horita A, Guy AW. Microwave irradiation affects radial-arm maze performance in the rat[J]. Bioelectromagnetics, 1994, 15(2): 95-104. DOI: 10.1002/bem.2250150202
[39] Pozzi D, Corradini I, Matteoli M. The control of neuronal calcium homeostasis by SNAP-25 and its impact on neurotransmitter release[J]. Neuroscience, 2019, 420: 72-78. DOI: 10.1016/j.neuroscience.2018.11.009
[40] Luo FL, Yang N, He C, et al. Exposure to extremely low frequency electromagnetic fields alters the calcium dynamics of cultured entorhinal cortex neurons[J]. Environ Res, 2014, 135: 236-246. DOI: 10.1016/j.envres.2014.09.023
[41] Wang H, Zhang J, Hu SH, et al. Real-time microwave exposure induces calcium efflux in primary hippocampal neurons and primary cardiomyocytes[J]. Biomed Environ Sci, 2018, 31(8): 561-571. DOI: 10.3967/bes2018.077
[42] Kumar M, Singh SP, Chaturvedi CM. Chronic nonmodulated microwave radiations in mice produce anxiety-like and depression-like behaviours and calcium- and NO-related biochemical changes in the Brain[J]. Exp Neurobiol, 2016, 25(6): 318-327. DOI: 10.5607/en.2016.25.6.318
[43] Paulraj R, Behari J. Biochemical changes in rat brain exposed to low intensity 9.9 GHz microwave radiation[J]. Cell Biochem Biophys, 2012, 63(1): 97-102. DOI: 10.1007/s12013-012-9344-3
[44] Tan SZ, Wang H, Xu XP, et al. Study on dose-dependent, frequency-dependent, and accumulative effects of 1.5?GHz and 2.856?GHz microwave on cognitive functions in Wistar rats[J]. Sci Rep, 2017, 7(1): 10781. DOI: 10.1038/s41598-017-11420-9
[45] Wang H, Tan SZ, Xu XP, et al. Long term impairment of cognitive functions and alterations of NMDAR subunits after continuous microwave exposure[J]. Physiol Behav, 2017, 181: 1-9. DOI: 10.1016/j.physbeh.2017.08.022
[46] Narayanan SN, Jetti R, Kesari KK, et al. Radiofrequency electromagnetic radiation-induced behavioral changes and their possible basis[J]. Environ Sci Pollut Res, 2019, 26(30): 30693-30710. DOI: 10.1007/s11356-019-06278-5
[47] Shahin S, Banerjee S, Singh SP, et al. 2.45?GHz microwave radiation impairs learning and spatial memory via oxidative/nitrosative stress induced p53-dependent/independent hippocampal apoptosis: molecular basis and underlying mechanism[J]. Toxicol Sci, 2015, 148(2): 380-399. DOI: 10.1093/toxsci/kfv205
[48] Hao YH, Li WC, Wang H, et al. Microwave radiation induces neuronal autophagy through miR-30a-5p/AMPKα2 signal pathway[J]. Biosci Rep, 2022, 42(4): BSR20212584. DOI: 10.1042/BSR20212584
[49] Hao YH, Li WC, Wang H, et al. Autophagy mediates the degradation of synaptic vesicles: a potential mechanism of synaptic plasticity injury induced by microwave exposure in rats[J]. Physiol Behav, 2018, 188: 119-127. DOI: 10.1016/j.physbeh.2018.02.005
[50] 陈湃韩, 陈慧峰, 邹剑明. 低剂量电离辐射长期接触健康效应研究进展[J]. 中国辐射卫生,2022,31(1):99-104. DOI: 10.13491/j.issn.1004-714X.2022.01.018
Chen PH, Chen HF, Zou JM. Research progress in health effects of long-term exposure to low-dose ionizing radiation[J]. Chin J Radiol Health, 2022, 31(1): 99-104. DOI: 10.13491/j.issn.1004-714X.2022.01.018
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