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| A Comparison of Doses for Conventional and Intensity Modulated Radiation Therapy after Breast-conserving Operation in Early-stage Breast Cancer |
| TIAN Lei1, LI Hui-cheng2, CHI Qi1, LU Xue1, LIU Xiao-lan1, WANG Tie-jun1 |
1. The Department of Radiotherapy of the Second Affiliated Hospital of Jilin University, Changchun 130000 China;
2. The Separtment of radiotherapy of General Hospital of Faw |
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Abstract Objective To compare the dosimetry distribution between conventional radiotherapy (CRT) and intensity modulated radiation therapy (IMRT) after breast-conserving surgery in early-stage breast cancer, and provide evidence for the application of IMRT in patients. Methods Twelve patients with early-stage breast cancer, who received breast conserving surgery, were selected in this study. CRT and IMRT plans with prescribed dose of 50 Gy/25 f were designed for each patient. The Dose volume histograms (DVHs) were used to evaluate the dosimetric distribution of the plan target volume (PTV) and the organs at risk (OARs) between the two plans. Results The V95% of PTV was similar in the two plans (98.22% vs 98.76%); The V105%、V110% of PTV in IMRT plans was 12.86%、1.02% versus 44.56%、6.37% in CRT plans(P < 0.05); The conformity index(CI) in IMRT plans was increased from 0.55 to 0.68, while the homogeneity index(HI) was decreased from 1.15 to 1.09(P < 0.05). Compared to CRT plans, the V30 and V20 of the ipsilateral lung in IMRT plans was reduced by 3.68% and 5.75%, the mean lung dose(MLD) was decreased from 9.24 Gy to 7.12 Gy(P < 0.05); In the left side patients, the V30、V40 and V50 of the heart in IMRT plans was reduced by 5.99%、5.68% and 1.68%, respectivly(P < 0.05). Conclusion Compared to CRT, IMRT decreased the high dose volume and improved the dose homogeneity with a satisfactory target coverage and effectively reduced the radiation dose for normal organs such as the heart and lungs.
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Received: 17 December 2013
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MIAO Hui, SHI Linxin, BAI Haisheng, SHAO Weixian, YUAN Cheng, LIU Yazhou, SUN Suping, CHEN Honglin, LUO Jujian, HUI Hua, ZHANG Wen. Dosimetric study on intensity-modulated radiotherapy with dissimilar position on peripheral normal tissues and organs of cervical cancer[J]. , 2018, 27(4): 381-384. |
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