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| Protective Effects of Parmelia Tinctorum Preparations on Acute Radiation-Injured Mice |
| HONG Ge, LI Song-nian, LIU Pei-xun, et al |
| Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192 China |
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Abstract Objective To investigate the radiation protection effect of Parmelia tinctorum preparations in dosage,drug administration time,administration methods and different preparation methods on acute radiation-injured mice,and find out the best therapeutic project.Methods Kunming mice were injected (ip) with 10 mg/kg,20mg/kg,40 mg/kg,80 mg/kg of Parmelia tinctorum preparations before irradiation respectively,then irradiated by 9 Gy 60Coγ-ray.The 30-day survival rates and the protection factors were observed.By the same method,another group of mice were injected (ip) with Parmelia tinctorum preparations at 15min,30min,1h,2h,4h before irradiation respectively,the 30-day survival rates and the protection factors were observed.The protective effect of Parmelia tinctorum preparations from intramuscular and oral routes were compared with the same method.The protective effect of Parmelia tinctorum water extract preparations and alcohol extract preparations were compared.Results A certain dosage (20-80 mg/kg) of Parmelia tinctorum preparations could greatly improve the 30-day survival rates and the protection factors of radiation-injured mice.Parmelia tinctorum preparations had significant therapeutic effect on 60Coγ-ray radiation-injured mice at 15min-1 h before irradiation.Administration of Parmelia tinctorum preparations by intramuscular injection showed a little lower efficacy than by intraperitoneal injection,but administration the same dose orally had no significant radiation protective effect.Parmelia tinctorum preparations extracted by water injected (ip) before irradiation had the same radiation protective effect with those extracted by 50% alcohol.Conclusion Parmelia tinctorum preparations have a certain protective effect on acute radiation-injured mice.The best therapeutic project is injected (ip) with 40mg/kg of Parmelia tinctorum preparations at 30min before irradiation.
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Received: 15 December 2008
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