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| Experimental Ressarch of Prednisolone in New Zealand White Rabbits with Radiation Induced Lung Injury |
| XING Yue-ming1, LI xiao-li2 |
| Department of radiotherapy, the No.2 Hosnpital of Shanxi Medical University, Taiyuan 030001 China |
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Abstract Objective To observe the preventive and therapeutic effect of Prednisolone in radiation injury of lungs.Methods 45 male New Zealand white rabbits were randomly divided into three groups with 15 in each;the blank group (a),the irradiation group (b) and the group with irradiation and Prednisolone (c).Group (a) has no other treatment.Group (b) was given injectons Sodium Chloride on the first day of irradiation,with 0.1 ml/kg/d for 4 weeks.Group (c) was given intraperitoneal injections of Prednisolone on the first day of irradiation,with 0.4 mg/kg/d for 4 weeks.CT scanning was performes before irradiation and the 1,3,5 months after the irradiation.The animals were killed by cutting off the neck after 1,3,5 months of radiation.The right lungs were removed to give HE staining and immunohistochemical staining for the histological evaluation.Results No significant changes were found in group a in CT scanning.The pathological chages in group c is less than serious than those in group b.Group c is less serious than in pathological changes those in group b.Immunohistochemical results;One,three,and five months after irradiation,the number of positive cells were highest in group b,and was significantly higher in group c than in group a.Conclusion High dose irradiation of the lung of New Zealand rabbit tissue can successfully abtain the established radiation-induced lung injury animal models.Prednisolon can reduce the radiation-induced lung injury in rabbits New Zealand,and has a certain preventive effect.
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Received: 27 October 2008
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