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| Effect of Rana Japonica Oil Compound Granules on the Expression of TGF-β2 mRNA in the Liver of the Microwave Radiation Rats under Hypergravity Environment |
| WANG Cheng, LV Shi-jie, PAN Wen-gan, et al |
| Jinlin Medical College, Jinlin 132013 China |
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Abstract Objective To study the effect of Rana Japonica Oil Compound Granules on the expression of TGF-β2 mRNA in the liver of the microwave radiation rats under hypergravity environment.Methods The models of Wistar rats under synergistic action of hypergravity environment and microwave radiation were established and intervened 14 days with Rana Japonica Oil Compound Granules to examines the expression of TGF-β2 mRNA in the liver from each group of rats by RTPCR.Results Compared with blank control group,the expression levels of TGF-β2 mRNA in the liver increased significantly in hypergravity radiation experimental group and hypergravity radiation after compound granules protection group (P<0.05) and significantly;decreased in compound granules experimental group and hypergravity radiation before compound granules protection group (P<0.05) and slightly decreased in hypergravity radiation In compound granules protection group,but no statistical significance (P>0.05).Conclusion Synergistic action of hypergravity environment and microwave radiation may strengthen the expression of TGF-β2 mRNA in the liver of rats;Rana Japonica Oil Compound Granules may reduce the expression of TGF-β2 mRNA in the liver of the normal rats and the microwave radiation rats under hypergravity environment.
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Received: 22 October 2008
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