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| Effect of radon hot springs on plasma 8-OHdG and TrxR in surrounding residents |
| GAO Yanxiao, TIAN Mei, GAO Gang, WU Lina, YI Lirong, LIU Jianxiang |
| Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection Chinese Center for Disease Control and Prevention, Beijing 100088 China |
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Abstract Objective To investigate the effects of long-term and repeatedly exposure to radon hot spring on oxidative damage and antioxidation in the population.Methods A simple random sampling method was used to select 46 residents around Radon Hot Spring in Ping Shan county as radon group, and 39 residents of Huishe township were selected as control group. Plasma levels of 8-OHdG and TrxR were measured by enzyme-linked immune sorbent assay (ELISA). The Mann-Whitney U test was used to compare the differential expression of 8-OHdG and TrxR between the two groups.Results The levels of 8-OHdG in peripheral plasma of residents with radon group were significantly decreased, and the levels of TrxR were significantly increased (Z=-3.350,-2.394,P<0.05), which were 0.622 times and 1.373 times that of the control group respectively. After the multiple linear regression analysis adjusted the factors of age, smoking, drinking, drinking tea and BMI, and residents radon exposure was associated with the differential expression of 8-OHdG and TrxR (t=-3.188,2.267,P<0.05).Conclusion Long-term and repeatedly exposure to radon hot springs can enhance the antioxidant capacity to a certain extent, and reduce the level of oxidative damage.
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Received: 01 September 2017
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