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| Antioxidant effects of human lactoferrin in mice by ionizing radiation |
| FENG Li1, WEI Chao2, LI Zhen3, SHANG Jie3, DENG Daping3 |
1. Shandong Provinical Qianfoshan Hospital, Jinan 250014 China;
2. Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College;
3. The Radiation Medical Institute, SAMS |
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Abstract Objective To study its influence on the 30th day suivival rate, the antioxidant in mice and to study the preventive effects of hLF on radiation damage as well as its possible mechanism.Methods The mice were randomly divided into three groups:normal control group、radiated control group and human lactoferrin protection group. The normal and radiated control groups were given isotonic Na chloride, once a day in seven days pre-irradiation.But protection group was given hLF, Mice in radiated control and protection group were exposed to X-ray after the last adminstration. All indexes were measured in the 24 h after radiation.Indexes include the 30-day survival rate of mice, the content of MDA, the SOD activity.The hepatic histopathologic changes were observed by microscopy.Results hLF could raise the 30-days survival rate of mice, and minimize the increasing degree of MDA and the decreasing degree of the activities of SOD. About protection group, liver damage reduced.Conclusion hLF can raise survival rate of radiated mice, enhance the their antioxidant ability. So we can conclude that the hLF may have some preventive effects on mice exposed to radiation.
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Received: 10 June 2017
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