|
|
|
| The protective role of therapeutic hypothermia in the 10 Gy irradiated Balb/C mice |
| WANG Yongli, LI Shufang, LIU Mengya, AN Quan, LI Jianguo, QIN Xiujun, WEN Jianhua, LIU Huan |
| China Institute for Radiation Protection, Taiyuan 030006 China |
|
|
|
|
Abstract Objective To investigate the protective role of therapeutic hypothermia in the acute and high-dose irradiated mice.Methods Two groups of Balb/C mice each 15 were received whole body irradiation with 60Co source. One group of mice were administered therapeutic hypothermia following irradiation. The indices of survival time, survival rate, protection index, and peripheral blood counts as well as paraffin-embedded tissue sections were observed.Results Survival time extended averagely 3.4 days and protection index attained 1.216 in the hypothermia-treated group compared with the group treated only with radiation.And both the reduction of lymphocytes and injuries of organs induced by irradiation were retarded in the hypothermia-treated group too,the number of lymphocytes at 6 hours and 24 hours after irradiation was higher than that of the group treated only with radiation.Conclusion Therapeutic hypothermia administered immediately following irradiation might play a protective role in mice exposure to high-dose irradiation.
|
|
Received: 15 June 2017
|
|
|
|
|
|
[1] 赵斌,张军帅,刘培勋.辐射防护剂研究现状及其进展[J].核化学与放射化学,2012,34(1):9-11.
[2] 秦秀军,田宇,安全,等.富氢水对小鼠辐射损伤的保护作用[J].辐射防护通讯,2013,33(4):28-33.
[3] 孙志扬,李光,孙庆文,等.心肺复苏大鼠行亚低温处理后不同脑区NMDARl表达变化[J].中国临床新医学,2009,2(9):889-893.
[4] 费华伟,程光,程爱国.亚低温在脊髓损伤治疗中的研究现状[J].中国医药导报,2012,9(9):11-13.
[5] Mancuso A, Derugin N, Hara K, et al. Mild hypothermia decreases the incidence of transient ADC reduction detected with diffusion MRI and expression of c-fos and hsp70 mRNA during acute focal ischemia in rats[J].Brain Res, 2000,887(1):34-45.
[6] Yager JY, Asselin J. Effect of mild hypothermia on cerebral energy metabolism during the evolution of hypoxic-ischemic brain damage in the immature rat[J].Stroke, 1996,27(5):919-925.
[7] Wang GJ, Deng HY, Maier CM, et al. Mild hypothermia reduces ICAM-1 expression, neutrophil infiltration And microglia/monocyte accumulation following experimental stroke[J].Neuro cience,2002,114(4):1081-1090. |
|
|
|
