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| Synthesis and Hypoxic Radiosensitization of N-(5-Nitroindazole-3-Formyl) Phenylalanine Sodium |
| WANG Hao, ZHOU Xiao-liang, ZHOU Ze-wei, SONG Na-ling |
| Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192 China |
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Abstract Objective To synthesize the N-(5-nitroindazole-3-formyl) phenylalanine sodium and investigate its hypoxic radiosensitization. Methods To synthesize the target compound using condensing agents, and investigated its radiosensitization under hypoxia using in vitro and in vivo models. Results The synthesis and structure of the target compound were confirmed. Cell and xenograft models showed that the compound had a certain radiosensitizing activity. Conclusion N-(5-nitroindazole-3-formyl) phenylalanine sodium had good radiosensitizing activity and was worthy of further studing.
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Received: 18 March 2015
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