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| Effects of 137Cs Gamma Irradiation on The Hematopoietic and Immune Function in Mice |
| ZHANG Li-juan, LU Lu, WANG Yue-ying, LI De-guan, ZHANG Jun-ling, MENG Ai-min, MA Rui |
| Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key laboratory of Molecular Nuclear Medicine, Tianjin 300192 China |
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Abstract Objective To observe the effect of irradiation on the hematopoietic and immune function of four kinds of mice, IRM-2、ICR、615 and C57BL/6J. Methods After the 4.0Gy radiation with 137Cs gamma ray, respectively peripheral blood classification was performed, bone marrow nucleated cells(BMNC) count and visceral index of the four kinds of mice were measured and the phagocytic function of peritoneal macrophages on chicken red blood cells were tested. Results The total number of WBC,the number of BMNC and macrophage phagocytosis rate of IRM-2 are higher than those of other strains, and the differences between IRM-2 and 615 or ICR or C57BL/6J were statistically significant(P < 0.01). The classification of the four kinds of mice white blood cells is basically consistent. Fourth weeks after irradiation, the differences in the number of WBC and BMNC in IRM-2 were statistically significant compared with 615 or ICR or C57BL/6J (P < 0.01). Conclusion IRM-2 mice have better hematopoietic and immune functions, and are good animal model applied in the experimental study.
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Received: 17 February 2015
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