间充质干细胞来源胞外囊泡救治辐射损伤的研究进展

doi:10.13491/j.issn.1004-714x.2018.04.022

2018, Vol. 27

Issue (4): 369-371 DOI: 10.13491/j.issn.1004-714x.2018.04.022

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Role of mesenchymal stem cell derived extracellular vesicles in radiation injuries

WANG Li^1,2, MA Dexun³, XU Changchun¹, GAO Rui¹, GAO Chunji², LIU Shufeng³

1. Department of Hematology and Oncology, Laoshan Branch of No. 401 Hospital of Chinese PLA, Qingdao 266101 China;
2. Department of Hematology, Chinese PLA General Hospital;
3. Department of radiation protection, Laoshan Branch of No. 401 Hospital of Chinese PLA

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Abstract Mesenchymal stem cell derived extracellular vesicles (MSC-EVs) conserve MSC' bioactivity, while overcome certain safety concerns related to MSC. The phospholipid bilayer of MSC-EVs may protect their contents, such as lipid, protein, DNA, RNA, from degradation by circulatory enzymes. Moreover, large scale MSC-EVs could be obtained through immortalized MSC technique. Thus, MSC-EVs based therapy is a more efficient, convenient, feasible, safer cell free therapy strategy compared with MSC. So far, MSC-EVs present similar function to MSC in the field of regenerative medicine and immunomodulation. Herein, the recent research progress about the role and the involved mechanisms of MSC-EVs in radiation injuries are systematically reviewed.

Key words： Mesenchymal Stem Cell Extracellular Vesicle Radiation Injury

Received: 12 February 2018

PACS:

R818

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	Articles by authors
	WANG Li
	MA Dexun
	XU Changchun
	GAO Rui
	GAO Chunji
	LIU Shufeng

Cite this article:

WANG Li,MA Dexun,XU Changchun, et al. Role of mesenchymal stem cell derived extracellular vesicles in radiation injuries[J]. , 2018, 27(4): 369-371.

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http://www.zgfsws.com/EN/10.13491/j.issn.1004-714x.2018.04.022 OR http://www.zgfsws.com/EN/Y2018/V27/I4/369

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