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| The Effects of Tea Polyphenols on Hprt Gene Locus Mutation of Peripheral Blood Lymphocytes in Mice After 60Co γ Exposure |
| LI Qi-hui1, TANG Mu-tao1, WANG Qian1, WANG Xiu-de1, ZHANG Hui-bin1, GU Qia-min1, SHANGGUAN Tao2, ZOU Zhong-min2, Zhao Yong1 |
1. Jinan Military Center of Disease Prevention and Control, Jinan 250014 China;
2 Institute of Toxicology, College of Preventive Medicine, Third Military Medical University |
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Abstract Objective To investigate the effects of tea polyphenols (TP) on Hprt gene locus mutation of peripheral blood lymphocytes in mice after 60Co γ-ray exposure. Methods The mice were divided into control group,γ-ray radiation group (1、2、4、8Gy radiation) and TP + γ-ray group (The mice were given a gavage of TP 725mg/kg, 145mg/kg, 29mg/kg after radiation respectively). Blood was collected from the mice hearts after 14 days and Hprt gene locus mutations were examined by polykaryocytes test. Results Hprt locus mutation was induced by 0~8Gy60Co γ rays. The frequency of Hprt locus mutation was significantly higher than that of the control, which increased linearly with doses and could be represented in a linear model Y=1.1795 + 0.6135D. The frequency of Hprt locus mutation of TP + γ-ray group was significantly decreased (P < 0.01) compared to the radiation group. Conclusion TP has protective effects on Hprt mutation induced by 60Co γ-ray.
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Received: 15 July 2016
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