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| The Anti-Oxygen Effect of Sodium Borocaptate on Radiation Mice |
| QIAN Tian-tian, HE Ying, WANG Qing-rong, CHEN Wei, Shen Xian-rong |
| Naval Medical Research Institute, Shanghai 200433 China |
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Abstract Objective To investigate the anti-oxygen effect of sodium borocaptate on radiation mice. Methods 42 BALB/c mice was randomly divided into negative control group, model control group, positive control group(WR2721,200 mg/kg), 20 mg/kg BSH group, 40 mg/kg BSH group, and 80 mg/kg BSH group. The preparations were administrated in peritoneal injection with 0.2 ml/20g. Negative control group and model control group were administrated with normal saline. Positive control group was administrated twice before irradiation. Irradiated mice were irradiated by γ-ray of 60Co (0.8 Gy/min) with the dose of 6 Gy. In 14 days after being irradiated, SOD and MDA were detected. Results Comparing with model control group, SOD in peripheral blood was increased significantly in the 20 mg/kg. d BSH group, 40 mg/kg. d BSH group and 80 mg/kg. d BSH group(P < 0.05). Comparing with the model control group, MDA was decreased significantly in the BSH treated groups (the 20 mg/kg. d group P < 0.05, the 40 mg/kg group and the 80 mg/kg group P < 0.01). Conclusion BSH has the effects of increasing the activity of SOD and decreasing the concentration of MDA on mice. The results suggest that BSH has the anti-oxygen activity and it should be one of the mechanisms of BSH on radioprotection.
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Received: 19 March 2011
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