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| The Therapeutic Effect Of Three-dimensional Conformal Radiation Therapy Combined with Conventional Radiotherapy for Nasopharyngeal Carcinoma |
| LIANG Feng, LV Zhong-hong, YAO Zhi-jun, CAO Yong-zhen |
| Department of Radiation Oncology, General Hospital of School Tianjin Medical University, Tianjin 300070 China |
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Abstract Objective To observe the therapeutic effect of three-dimensional conformal radiation therapy (3DCRT) for nasopharyngeal carcinoma (NPC). Methods 78patients with NPC was treated by radiation schedule in two phases. In the first phase, nasopharyngeal lesions and metastases of all patients were treated by three-dimensional conformal radiation therapy (3DCRT) with a fraction of 2-5Gy daily, 5 day per weeks, total dose 30Gy. The second phase T1N0 or parts of T2N0 patients were done by Conventional radiotherapy with total dose 55Gy on two small lateral opposing fields + with total dose 50Gy on neck on tangential field, adding a 3cm block. Patients with lymph node metastasis were given 55Gy on the dacio-neck field (After 40Gy, two small lateral opposing fields were used to boost the primary tumor while the spinal cord shielded) + with total dose 55Gy on lower neck on tangential field. The upper bound of designed therapeutic field was set to connect with lower bound of main therapeutic field. Results Three months after treatment,the rate of CR、PR、SD、PD were 38.5%、55.1%、5.1%、1.3%, Total effective rate(CR + PR) were 93.6%. The 1-year、2-year、3-year and 5-year local-regional control rates were 92.3%、88.5%、78.2%、70.5%. The 1-year、2-year、3-year and 5-year overall survival rate were 96.2%、89.7%、83.3%、71.8%. Appearing early radiation response is well tolerated and no obviously mouth difficulties and cranial nerve damage observed. Conclusion Clinical result of early-course three-dimensional conformal radiation therapy (3DCRT) for nasopharyngeal carcinoma (NPC) is good.
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Received: 19 June 2011
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