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| Investigation of Radioprotective Effects of Aqueous Extract of Sauseurea Obyallata on Immune System of Mice |
| ZHANG Guo-liang, LI Wen-hui, GUO Na, et al |
| Radiation Oncology Center, The Third Affiliated Hospital of Kunming Medical College/Yunnan Tumor Hospital, Kunming 650118 China |
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Abstract Objective To investigate the radioprotective effects of test compound on immune system of mice from radiation injury.Methods Immunologic function and general state of mice were shown by swimming experiment with the weighing of spleen,thymus and computing their indexs,hemolysin mensurate experiment and PHA stimulated lymphocyte transformation experiment.All mice were irradiated with 6 Gy and received the test compound by gavage for 14 days,7days before irradiation and 7days after irradiation.All the indicators were measured according to established methods.The data went through Statistical analysis by spss11.5.Results Irradiation has obvious influence on the immune function and systemic state of mice.In swimming experiment,mice in the treatment group swim longer than the model group,but is of no significant difference.The thymus indexes are higher in treatment groups than in model group,especially the HD group,compared with model group,the differences are obvious (P < 0.05).There is no obvious difference between treatment groups and model group with OD value in hemolysin mensurate experiment.Conclusions Aqueous Extract of Sauseurea Obyallata may have radioprotective effects on immune system of mice,which deserves further exploration in the compound preparing,analysis of Chemical Compositions and the dose and mode and the treatment duration of the compound.
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Received: 28 December 2010
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