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| Setting-up of Radiation-Induced Kidney Injury in Rat Model and Evaluation of Image Manifestations |
| MAO Yu1, CAO Yong-zhen1, ZHOU Yan1,2, WEI Jian2, LI Su-fen1,2, ZHANG Wen-xue1, GENG Kai1, ZHANG Yin-ling1 |
| Department of Radiation Oncology, General Hospital of Tianjin Medical University, Tianjin 300052 China |
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Abstract Objective To study the setting-up methods of radiation-induced kidney injury in rat model, the pathological changes of in the early phase of radiation-induced kidney injury, and assess the diagnostic value of CT and MRI in the early phase of radiation-induced kidney injury. Methods Forty-eight Sprague Dawley rats were randomly divided into one normal control group and two experimental groups, and the experimental groups received a single dose of 20 Gy to the left kidney. Images of CT and MRI were obtained and pathological observation on the kidneys at 4, 12, 24, 36 weeks. Results CT、MRI findings including kidney atrophy and the thin of kidney parenchyma and the loss of corticomedullary differentiation were observed at the scheduled study. Radiation nephropathy was detected earlier with MRI than CT, and the sensitivity of MRI was higher than that of CT (P < 0.05). Pathological observation showed the morphological changes at 4 weeks after irradiation,including glomerular and tubular injury. An improvement in glomerular and tubular lesions was observed by 12、24、36 weeks after irradiation. Conclusion The radiation-induced kindey injury model can be setting up with the exposure of a single dose of 15 Gy radiation to the unilateral kidney of sprague dawley rats and morphological changes was observed. Early diagnosis of radiation-induced kidney injury can be performed with MRI scanning better than CT.
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Received: 02 August 2012
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