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| Research progress of radiation-induced cardiovascular diseases |
| HUANG Yong |
| Department of Oncology, Guangde Road, Hefei Second People's Hospital, Hefei 230011 China |
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Abstract Cancer survival has improved dramatically, but this has also increased the delayed side effects of multimodality therapy. Radiation (RT) to the thoracic malignancies results in unintentional irradiation of the cardiac chambers. RT-induced microvascular ischemia leads to disruption of capillary endothelial framework, and injury to differentiated myocytes results in deposition of collagen and fibrosis. Radiotherapy not only causes heart damage, but also accelerates the occurrence of major coronary events in patients with metabolic syndrome and atherosclerosis. Hence, it becomes pertinent to understand the underlying pathophysiology and clinical manifestations of RT-induced cardiovascular disease to devise optimal preventive and surveillance strategies.
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Received: 05 March 2018
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