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| Research progress in hematopoietic stem cell transplantation for bone marrow acute radiation syndrome |
| WANG Jing1, ZHOU Fang2 |
1. Jinzhou Medical University PLA Joint Logistics Support Unit 960 Hospital Postgraduate Training Base, Ji'nan 250031 China;
2. Department of Hematology, The People’s Liberation Army No.960 Hospital, Ji'nan 250031 China |
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Abstract As is known, the nuclear accident resulting from the explosion of a nuclear weapon or the release of nuclear material could cause acute radiation syndrome within a short time. The study had found that the dose of > 0.7 Gy radiation on human body can result in persistent myelosuppression, a kind of acute radiation syndrome, leading to pancytopenia, bleeding, infection and other injuries. Several evidences also have shown that hematopoietic stem cell is conducive to repair hematopoietic injury in bone marrow, improve hematopoietic microenvironment and promote hematopoietic reconstruction. Therefore, hematopoietic stem cell transplantation is widely considered as the main treatment of the bone marrow acute radiation syndrome. However, before a surgery of hematopoietic stem cell transplantation, it still needs more research on donor selection, formulation of preconditioning and prevention of complications such as graft-versus-host disease. This paper mainly summarizes the application and research progress of hematopoietic stem cell transplantation in treating radiation injury.
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Received: 12 November 2020
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