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| Effects of 60Co-γ ray irradiation sterilization on the quality of Whitmania pigra medicinal powder |
| ZHANG Wei1,2, HAN Zhenming1,2, YANG Mei1,2, GUAN Yongxia1,2, MA Yun1,2, DU Haochen1,2, ZHANG Guimin2,3 |
1. Lunan Houpu Pharmaceutical Co., Ltd., Linyi 276006 China;
2. State Key Laboratory of Generic Manufacture Technology of Traditional Chinese Medicine;
3. Lunan Pharmaceutical Group Co., Ltd. |
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Abstract Objective To study the effect of 60Co-γ ray irradiation sterilization on the composition and hygiene index of leech medicine powder, and provide a basis for the improvement of leech sterilization process.Methods Irradiation sterilization of leech powder with different doses of 60Co-γ rays, measure moisture, total ash, acid-insoluble ash, pH value, heavy metals and harmful elements, aflatoxin, anticoagulant activity according to pharmacopoeia requirements and other hygienic indicators such as microbial content before and after sterilization. The chemical constituents of leech powder sterilized by irradiation with different doses of 60Co-γ rays were analyzed by HPLC.Results There were no significant difference in moisture, total ash, acid-insoluble ash, pH value, heavy metals and harmful elements, aflatoxin and anticoagulant activity in the peony powder before and after irradiation with different doses of 60Co-γ rays. Before and after sterilization with different doses of 60Co-γ ray irradiation, the hygienic parameters of the experimental groups were significantly different. Dynamic irradiation with 60Co-γ rays at 8 kGy and above could effectively kill microorganisms. There were no significant differences in 7 chemical components before and after sterilization by HPLC, and the quality was stable before and after sterilization.Conclusions 60Co-γ ray irradiation can effectively kill microorganisms in medicinal powder, and the dose effect of 8～10 kGy is the best. There is no significant difference in the pharmacopoeia check items before and after irradiation sterilization, and the quality of the powder after irradiation is better.
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Received: 07 January 2020
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