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| Research on patient dose in 18F-FDG and 18F-FET PET-CT examinations |
| LI Ning, HE Zhengzhong, YANG Zhi, YANG Hongyu, LIAO Guangxing, LUO Yu, CHAI Hua, LI Dangsheng, XIAO Guoyou |
| Department of Nuclear Medicine, Cancer Hospital, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021 China |
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Abstract Objective To estimate the effective and organ dose of patients receiving the 18F-FDG (18F-2-deoxy-D-glucose) and 18F-FET (O-2-18F- fluoroethyl -L-tyrosine) PET-CT whole body examinations.Methods Two PET-CT scanning protocols were used for whole body imaging. The effective and organ dose of PET part were calculated using the internal dose computer program IDAC 2.1 based on MIRD method. The effective and organ doses of CT part were calculated by VirtualDose software, and the sum of CT and PET dose was the total effective dose of patients.Results In the conventional PET-CT scan protocol, the effective dose was (4.81 ±1.04) mSv for male and (6.09 ±0.73) mSv for female patients from 18F-FDG; the effective dose was (2.67 ±0.38) mSv for male and (3.21 ±0.38) mSv for female patients from 18F-FET; the effective dose was (5.63 ±0.32) mSv for male and (5.51 ±0.29) mSv for female patients from CT component. The total effective dose was (10.44 ±1.09) mSv for male and (11.60 ±0.79) mSv for female from 18F-FDG PET-CT examination, respectively. Whereas it was (8.30 ±0.50) mSv for male and (8.72 ±0.49) mSv for female from 18F-FET PET-CT examination, respectively. In the diagnostic-quality CT scan protocol, the effective dose was (16.28 ±1.01) mSv for male and (13.49 ±0.72) mSv for female patients from CT component. The total effective dose was (21.09 ±1.45) mSv for male and (19.58 ±1.03) mSv for female patients from 18F-FDG, respectively. Whereas it was (18.95 ±1.08) mSv for male and (16.70 ±0.81) mSv female patients from 18F-FET.Conclusion Different PET-CT scan parameters caused the patient to be exposed to different radiation doses. In the daily work, we should optimize the acquisitive parameters of PET and CT according to the actual situation of the examinee, and reduce the dose of examinee to practice the optimization of radiation protection.
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Received: 02 March 2019
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