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| Meta-analysis of cohort studies on radiation exposure from CT scans in childhood and subsequent cancer risk of leukaemia and brain tumors |
| NIU Yating1, SU Yinping1, NIU Yantao2, SUN Quanfu1 |
1. Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100086 China;
2. Department of Radiology, Beijing Tongren Hospital, Capital Medical University |
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Abstract Objective To quantitatively estimate the radiation exposure from CT scans in childhood and subsequent cancer risk of leukemia and brain tumors.Methods We retrieved six databases, including Wanfang Database, China National Knowledge Infrastructure, China Biology Medicine disc, MEDLINE, Pubmed, The Cochrane Library, and summarized large-scale cohort studies on CT scans in childhood and subsequent cancer risk which published at home and abroad before 2019. Meta-analysis was performed using relative risk (RR) and its 95% confidence intervals.Results There are five literatures included the analysis. The RR between leukemia and brain tumors was 1.59 (95% CI: 1.24, 2.05) and 2.07 (95% CI: 1.50, 2.86) respectively. CT scans increased the risk of leukemia and brain tumors.Conclusion Radiation exposure of CT scans in childhood can increase the risk of leukemia and brain tumors. It is important to reduce the radiation dose in children as much as possible without compromising the clinical diagnostic value of the image.
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Received: 09 September 2019
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