|
|
Diagnostic analysis of radiational gonad disease |
LIU Libo, PIAO Chunji |
School of Public Health Jilin University, NHC Key Laboratory of Radiobiology, Changchun 130021 China |
|
|
Abstract The gonadal diseases caused by ionizing radiation are called radiational gonad disease which include radiation infertility and radiation amenorrhea. Radiation induced gonad disease mainly occure in accidental exposure, occupational exposure and medical exposure. In order to better understand radiation induced gonad disease and correct diagnosis and treatment in this paper, we analyzed the pathogenesis, clinical manifestations, laboratory examination, diagnosis, differential diagnosis, treatment and prognosis of radiation induced gonad disease.
|
Received: 19 June 2019
|
|
|
|
|
[1] Grignard E,Guéguen Y,Grison S,et al.Testicular steroidogenesis is not altered by 137 cesium Chernobyl fallout,following in utero or post-natal chronic exposure[J].Comptes Rendus Biol,2010,333(5):416-423. [2] 杨增明,孙青原,夏国良.生殖生物学[M].北京:科学出版社,2005. [3] 王玉珏,岳敏,林继红,等.不同剂量X射线辐射对睾丸生物学效应的影响[J].实用医学杂志,2015,31(1):17-20. [4] Gliki G,Ebnet K,Aurrand-Lions M,et al.Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C[J].Nature,2004,431(7006):320-324. [5] Madani A H,Falahatkar S,Heidarzadeh A,et al.Sensitivity and specificity of serum FSH and testis size in predicting the existence of spermatogenesis in azoospermic infertile men[J].Andrologia,2012,44(3):205-209. [6] Colpi G M,Contalbi G F,Nerva F,et al.Testicular function following chemo-radiotherapy[J].Eur J Obstet Gynecol Reprod Biol,2004,113(Suppl 1):S2-S6. [7] Howell S J.Spermatogenesis after cancer treatment:damage and recovery[J].J Natl Cancer Inst Monogr, 2005(34):12-17. [8] Gurkan H,Kucukdurmaz F,Akman T,et al.Screening for y chromosome microdeletion in a nonobstructive azoospermic male patient with allogeneic bone marrow transplantation from his sister[J].Case Rep Med,2010,2010:541061. [9] Tran S,Boissier R,Perrin J,et al.Review of the different treatments and management for prostate cancer and fertility[J].Urology,2015,86(5):936-941. [10] 龚守良.医学放射生物学[M].北京:原子能出版社,2015. [11] Verstegen J,Iguer-Ouada M,Onclin K.Computer assisted semen analyzers in andrology research and veterinary practice[J].Theriogenology,2002,57(1):149-179. [12] Woon J H,Shin S C,Kang Y M,et al.Sperm abnormalities in high- and low-dose-rate Gamma-irradiated Korean dark-striped field mice,Apodemus agrarius coreae[J].Radiat Prot Dosimetry,2011,146(1-3):280-282. [13] Kumar D,Salian S R,Kalthur G,et al.Semen abnormalities,sperm DNA damage and global hypermethylation in health workers occupationally exposed to ionizing radiation[J].PLoS One,2013,8(7):e69927. [14] Kamiguchi Y,Tateno H,Mikamo K.Types of structural chromosome aberrations and their incidences in human spermatozoa X-irradiated in vitro[J].Mutat Res,1990,228(2):133-140. [15] 傅宝华,刘金荣,吕玉民,等.60Co全身照射诱发人精子染色体畸变的研究[J].中华放射医学与防护杂志,1995,15(1):10-13. [16] Adiga S K,Upadhya D,Kalthur G,et al.Transgenerational changes in somatic and germ line genetic integrity of first-generation offspring derived from the DNA damaged sperm[J].Fertil Steril,2010,93(8):2486-2490. [17] Barratt C L,Aitken R J,Björndahl L,et al.Sperm DNA:organization,protection and vulnerability:from basic science to clinical applications——a position report[J].Hum Reprod,2010,25(4):824-838. [18] 高伟.X射线对子宫内膜及卵巢生殖功能影响的分子机制的研究[D].大连:大连医科大学,2015. [19] Jang H,Hong K,Choi Y.Melatonin and fertoprotective adjuvants:prevention against premature ovarian failure during chemotherapy[J].Int J Mol Sci,2017,18(6):E1221. [20] Aktas C,Kanter M,Kocak Z.Antiapoptotic and proliferative activity of curcumin on ovarian follicles in mice exposed to whole body ionizing radiation[J].Toxicol Ind Health,2012,28(9):852-863. [21] Teng P N,Bateman N W,Darcy K M,et al.Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian,endometrial,and cervical cancer cells[J].Gynecol Oncol,2015,136(3):554-561. [22] 龚守良.电离辐射生殖遗传效应[M].北京:原子能出版社,2009. [23] 谢幸,苟文丽.妇产科学[M].第8版.北京:人民卫生出版社,2013. [24] 世界卫生组织著,曹坚等译.不孕夫妇标准检查与诊断手册[M].北京:科学出版社,1995. [25] WHO. Infertility definitions and terminology.http://www.who.int/reproductivehealth/topics/infertility/definitions/en/ [26] 乐杰.妇产科学[M].第7版.北京:人民卫生出版社,2008. [27] 中华医学会妇产科学分会内分泌学组.闭经诊断治疗指南[J].中华妇产科杂志,2011,46(9):712-716. |
|
|
|