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| Expert interpretation on the significance of chromosomal aberration in the assessment of acute and chronic radiation damage |
| LV Yumin |
| Henan Institute of Occupational Medicine, Zhengzhou 450052 China |
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Abstract The significance and value of chromosomal aberration analysis of peripheral blood lymphocyte in the estimation of acute radiation biological dose, reconstruction of early accident radiation dose and evaluation of biological effect of chronic low-dose radiation have been widely recognized by the international academic community, and abundant data have been accumulated. Therefore, this paper will make a brief interpretation on the application and significance of chromosomal aberration analysis in the assessment of acute-and chronic-radiation injury.
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Received: 11 May 2019
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[1] Bender M A, Gooch P C. Types and rates of x-ray-induced chromosome aberrations in human blood irradiated in vitro[J]. Proceedings of the National Academy of Sciences, 1962, 48(4):522-532.
[2] Bender M A, Gooch P C. Somatic chromosome aberrations induced by human whole-body irradiation:the "recuplex" criticality accident[J]. Radiation Research, 1966, 29(4):568-582.
[3] 金璀珍,刘秀林.上海"6.25"60Co源辐射事故病人受照生物剂量(淋巴细胞染色体畸变)的估计[C]/上海"6.25"60Co源辐射事故病人诊断与救治文集, 1994:26-32.
[4] 高宇,王平,韩林,等.放射工作人员染色体畸变研究现状[J].中华放射医学与防护杂志, 2018, 38(8):635-640.
[5] Lloyd D C. Biological dosimetry after accidents. In:Obe G, Natarajan AT, eds[M].Chromosomal aberrations basis and applied aspects.Springer-Verlag Berlin, 1990:212.
[6] Ramalho A T, Nascimento A C H, Natarajan A T. Dose assessments by cytogenetic analysis in the goiania (Brazil) radiation accident[J]. Radiation Protection Dosimetry, 1988, 25(2):97-100.
[7] 白玉书,黄绮龙,关树荣.忻州事故中34例受检者染色体畸变分析和生物剂量估算[J].中华放射医学与防护杂志,1995,15(2):84-87.
[8] 陈英,刘秀林,姚波,等.山东济宁辐射事故受照人员生物剂量估算及彗星电泳检测分析[J].中华放射医学与防护杂志,2007,27(1):22-25.
[9] 陈英,杜杰,张学清,等.太原"4.11"钴源事故受照者生物剂量估算及照后一年细胞遗传学随访[J].辐射防护,2010,30(4):201-207.
[10] 吕玉民,傅宝华,韩林,等.河南"4.26"60Co源辐射事故受照者的生物剂量(染色体畸变)估算[J].中华放射医学与防护杂志,2001,21(3):153-155.
[11] 金璀珍,刘秀林,张泽云.一例192Ir源辐射事故病人受照生物剂量的估算[J].中华放射医学与防护杂志,1997,17(1):34-36.
[12] 戴宏,刘玉龙,王优优,等.南京"5.7"192Ir源放射事故患者的生物剂量估算[J].中华放射医学与防护杂志, 2016, 36(5):350-354.
[13] Deperas J, Szluinska M, Deperas-Kaminska M, et al. CABAS:a freely available PC program for fitting calibration curves in chromosome aberration dosimetry[J]. Radiation Protection Dosimetry, 2007, 124(2):115-123.
[14] 姚波,蒋本荣,邱立娟,等.一例亚急性放射病患者的生物剂量估算及细胞遗传学随访观察[J].中华放射医学与防护杂志,2007,27(2):154-157.
[15] 陈英,刘秀林,张学清,等.哈尔滨辐射事故受照者生物剂量估计和远后效应评价[J].中华放射医学与防护杂志,2006,26(2):125-128.
[16] International Atomic Energy Agency. Cytogenetic dosimetry:applications in preparedness for response to radiation emergencies[R]. Vienna:IAEA, 2011.
[17] Romm H, Ainsbury E, Barnard S, et al. Automatic scoring of dicentric chromosomes as a tool in large scale radiation accidents[J]. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2013, 756(1/2):174-183.
[18] Vaurijoux A, Gruel G, Pouzoulet F, et al. Strategy for population triage based on dicentric analysis[J]. Radiation Research, 2009, 171(5):541-548.
[19] Gruel G, Grégoire E, Lecas S, et al. Biological dosimetry by automated dicentric scoring in a simulated emergency[J]. Radiation Research, 2013, 179(5):557-569.
[20] Li Y X, Shirley B C, Wilkins R C, et al. Radiation dose estimation by completely automated interpretation of the dicentric chromosome assay[J]. Radiation Protection Dosimetry, 2019:1-6.
[21] Romm H, Ainsbury E, Bajinskis A, et al. Web-based scoring of the dicentric assay, a collaborative biodosimetric scoring strategy for population triage in large scale radiation accidents[J]. Radiat Environ Biophys, 2014, 53(2):241-254.
[22] Romm H, Ainsbury E A, Barquinero J F, et al. Web based scoring is useful for validation and harmonisation of scoring criteria within RENEB[J]. International Journal of Radiation Biology, 2017, 93(1):110-117.
[23] 戴宏,刘玉龙,冯骏超,等.双着丝粒染色体自动分析生物剂量估算研究[J].中华放射医学与防护杂志, 2017, 37(3):182-186.
[24] Ramakumar A, Subramanian U, Prasanna P G S. High-throughput sample processing and sample management; the functional evolution of classical cytogenetic assay towards automation[J]. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2015, 793:132-141.
[25] Royba E, Repin M, Pampou S, et al. RABiT-Ⅱ-DCA:A fully-automated dicentric chromosome assay in multiwell plates[J]. Radiation Research, 2019, 192(3):311-323.
[26] Wilkins R, Rodrigues M, Beaton-Green L. The application of imaging flow cytometry to high-throughput biodosimetry[J]. Genome Integr, 2017, 8(1):7.
[27] Lucas J N, Hill F, Burk C, et al. Dose-response curve for chromosome translocations measured in human lymphocytes exposed to 60Co gamma rays[J]. Health Physics, 1995, 68(6):761-765.
[28] Lucas J N, Awa A, Straume T, et al. Rapid translocation frequency analysis in humans decades after exposure to ionizing radiation[J]. International Journal of Radiation Biology, 1992, 62(1):53-63.
[29] Lucas J N. Dose reconstruction for individuals exposed to ionizing radiation using chromosome painting[J]. Radiation Research, 1997, 148(5):S33.
[30] Sotnik N V, Azizova T V, Darroudi F, et al. Verification by the FISH translocation assay of historic doses to Mayak workers from external gamma radiation[J]. Radiat Environ Biophys, 2015, 54(4):445-451.
[31] Tawn E J, Curwen G B, Jonas P, et al. Chromosome aberrations determined by FISH in radiation workers from the sellafield nuclear facility[J]. Radiation Research, 2015, 184(3):296-303.
[32] Lee J K, Lee M S, Moon M H, et al. Translocation frequency in patients with repeated CT exposure:comparison with CT-naive patients[J]. Radiation Research, 2019, 192(1):23-27.
[33] McKenna M J, Robinson E, Taylor L, et al. Chromosome translocations, inversions and telomere length for retrospective biodosimetry on exposed US atomic veterans[J]. Radiation Research, 2019, 191(4):311-322.
[34] 刘青杰,陈晓宁,姜恩海,等.多色荧光原位杂交技术的建立及其在早先受照射者剂量重建中的应用[J].中华放射医学与防护杂志, 2003,23(2):77-82.
[35] Liu Q J, Lu X, Zhao X T, et al. Assessment of retrospective dose estimation, with fluorescence in situ hybridization (FISH), of six victims previously exposed to accidental ionizing radiation[J]. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2014, 759:1-8.
[36] Chen Y, Jin C Z, Zhang X Q, et al. Seventeen-year follow-up study on chromosomal aberrations in five victims accidentally exposed to several Gy of 60Co γ-rays[J]. Radiat Environ Biophys, 2009, 48(1):57-65.
[37] Wang Z D, Zhang X Q, Du J, et al. Continuous cytogenetic follow-up, over 5 years, of three individuals accidentally irradiated by a cobalt-60 source[J]. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2015, 779:1-4.
[38] 李进,王芹,唐卫生,等.用G-显带法和荧光原位杂交对医用诊断X射线工作者细胞遗传学分析和剂量重建[J].中华放射医学与防护杂志,2003,23(4):260-262.
[39] 中华人民共和国国家卫生和计划生育委员会.GBZ 248-2014放射工作人员职业健康检查周血淋巴细胞染色体畸变检测与评价[S].北京:中国标准出版社, 2014.
[40] Alexanin S S, Slozina N M, Neronova E G, et al. Chromosomal aberrations and sickness rates in Chernobyl clean-up workers in the years following the accident[J]. Health Physics, 2010, 98(2):258-260.
[41] Goodhead D T. Fifth warren K. sinclair keynote address:issues in quantifying the effects of low-level radiation[J]. Health Physics, 2009, 97(5):394-406.
[42] Bonassi S, Norppa H, Ceppi M, et al. Chromosomal aberration frequency in lymphocytes predicts the risk of cancer:results from a pooled cohort study of 22358 subjects in 11 countries[J]. Carcinogenesis, 2008, 29(6):1178-1183.
[43] Wang H K, Wang Y, Kota K K, et al. Strong associations between chromosomal aberrations in blood lymphocytes and the risk of urothelial and squamous cell carcinoma of the bladder[J]. Sci Rep, 2017, 7:13493.
[44] Sun Z J, Inskip P D, Wang J X, et al. Solid cancer incidence among Chinese medical diagnostic X-ray workers, 1950-1995:Estimation of radiation-related risks[J]. Int J Cancer, 2016, 138(12):2875-2883.
[45] Wang F R, Fang Q Q, Tang W M, et al. Nested case-control study of occupational radiation exposure and breast and esophagus cancer risk among medical diagnostic X ray workers in Jiangsu of China[J]. Asian Pacific Journal of Cancer Prevention, 2015, 16(11):4699-4704. |
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