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| Effect of Low-dose rate 60Co γ-ray Ionizing Radiation on SD Rats |
| HOU Deng-yong, SHEN Xian-rong, HE Ying, CHEN Wei, QIAN Tian-tian, MO Lin-fang, WANG Yan, JIANG Ding-wen, LIU Yu-ming, LI Ke-xian, WANG Qing-rong |
| Navy Medical Institute, Shanghai 200433 China |
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Abstract Objective To study the effect of low-dose rate 60Co γ ionizing radiation on rats and provide theory foundation for protection of γ radiation. Methods SD rats were cumulative exposed to 60Co γ-ray. The expose time was 1 hour for every day and dose rate was 0.072 Gy/h. After 7 days, the accumulated dose reached 0.5 Gy and the associated changes in rats were measured. Results After irradiation, the average number of peripheral white blood cells of rats in experimental group(EG) was 3.50×109/L, while that of the rats in control group was 6.2×109/L. The decrease in EG is siginificant (P < 0.05). Other parameters in blood RT including platelet are of No significant difference. The average value of absorbance at OD260 of DNA in marrow of rats in EG was 1.083, while that of the rats in control group was 1.304. The decrease in rats of EG is significant (P < 0.05). The activity of SOD in serum of rats in EG was 373.83 U/ml, while that of the rats in control group was 421.59 U/ml. The decrease in rats of EG is significant (P < 0.05). Compared to the rats in control group, the main organ coefficients of rats in EG showed no significant difference. Conclusion Low-dose γ ionizing radiation have severe impairment effect on hematopoietic system and anti-oxidation system. It has no obviously effect on the organ coefficients of the main organs of rats.
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Received: 18 August 2011
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