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| Combined effect of 60Coγ-ray and B (a) P on HPRT mutation of human embryo lung cells |
| Fan Feiyue, et al |
| Institute of Radiation Medicine, Beijing 100850 |
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Abstract HPRT mutation of human embryo lung cells induced by 60Coγ-ray and benzo (a) pyrene was observed in order to study combined effect of radiation and B (a) Pon HPRT mutation of human embryo lung cells. HPRT mutation of the cells occurred after exposed to a different doses of γ-irradiation and B (a) P. Frequencies of HPRT mutations of the cells increased gradually with increase of doses of γ-irradiation and B (a) P. Relationship be tween HPRT mutation and doses of γ-ray or B (a) P was fit into the positive linear corr elation. Variants of HPRT mutation of the cells increased from 0.01±0.02 of control to 0.20±0.02 of 1Gyγ-irradiation and to 0.18±0.03 of lμg/ml B (a) P separately. The variant of the cells exposed to 1Gy γ-ray and lμg/ml B (a) P reached 0.40±0.04, which was not only higher than control's, but also higher than that of γ-ray or B (a) P. The result show ed there was the potentate effect of combined exposure to 60Coγ-irradiation and B (a) P on HPRT mutation of human embryo lung cells.
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Received: 16 March 1997
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LI Qi-hui, TANG Mu-tao, WANG Qian, WANG Xiu-de, ZHANG Hui-bin, GU Qia-min, SHANGGUAN Tao, ZOU Zhong-min, Zhao Yong. The Effects of Tea Polyphenols on Hprt Gene Locus Mutation of Peripheral Blood Lymphocytes in Mice After 60Co γ Exposure[J]. , 2016, 25(6): 645-647. |
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