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| A Study of Deformable Image Registration of Intensity Modulated Radiation Therapy CT Image to High-Dose-Rate Brachytherapy CT Image |
| ZHEN Xin, CHEN Hai-bin, XIAO Yang, HU Jie, ZHOU Ling-hong |
| School of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, 510515 China |
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Abstract Objective To propose a novel method for theintensity modulated radiation therapy (IMRT) CT image to the high-dose-rate brachytherapy (HDR) CT image deformable image registration and dose accumulation. Methods The applicator in the HDR CT image is first segmented and removed, and the Demons algorithm is utilized to register the IMRT CT image to the deflated HDR CT image. The deflated applicator mask is used to locate the position of the vagina in the deformed IMRT CT image, and the vagina is then inflated using Demons. In this way, the IMRT CT image is finally registered to the HDR CT domain, along with the IMRT dose for dose accumulation. Results IMRT CT image and HDR CT image, as well as the corresponding IMRT dose and HDR dose, from the gynecologic cancer patients are used for the evaluation of the proposed method. The results show that our method can effectively get rid of the influence of the applicator and produce an accurate accumulated dose. Conclusions Dose accumulation and supervision are important steps in adaptive radiotherapy for accurate dose delivery and treatment plan re-optimization. This study proposes a novel method for IMRT-HDR CT deformable image registration and dose accumulation, and the accuracy is proved to be sufficient for clinical needs.
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Received: 15 April 2014
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MIAO Hui, SHI Linxin, BAI Haisheng, SHAO Weixian, YUAN Cheng, LIU Yazhou, SUN Suping, CHEN Honglin, LUO Jujian, HUI Hua, ZHANG Wen. Dosimetric study on intensity-modulated radiotherapy with dissimilar position on peripheral normal tissues and organs of cervical cancer[J]. , 2018, 27(4): 381-384. |
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