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| The Protection of Glutamine on Radiation-induced Intestinal Mucosa Injury in Rats |
| LIN Hong, WU Wei, ZHANG Kun-he, et al |
| The First Affiliated Hospital, Jiangxi Medical College, Nanchang 330006, China |
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Abstract Objective To observe the protection of glutamine on radiation-induced intestinal mucosa injury.Methods Thirty rats were randomly divided into normal control group (group A), radiation control group (group B) and glutamine protection group (group C).The rats were received abdominal radiation of 1 000 cGy.Feeding glutamine began since the day before radiation in group C.Four days later, the rats were killed, and the intestinal bacteria translocation, the concentration of endotoxin in blood and pathological changes of intestinal mucosa were measured or observed.Results Bacteria translocation was not found in group A, but evident in group B, and much lighter in group C than in group B.The concentration of endotoxin in blood was very low in group A, very high in group B.but much lower in group C than in group B.The villus edema, mucosa infiltrated with informative cells and epithelial exuviation were found in group B, but these pathological changes were much lighter in group C, and not found in group A.Conclusion Whole abdomen radiation will evidently cause intestinal mucosa injury in rats, and bacteria translocation and endotoxinemia would occur.Glutamine can prevent those changes.
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Received: 03 January 2001
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