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| Effects of Lead on Biomarkers of Oxidative Damage and Energy Metabolism in the Blood of Battery Workers |
| ZHU Wen-wen1,2, SHAO Hua2, FENG Bin2, WANG Cui-juan2, WEI Hai-yan2, CHEN Wen-wen2, CHEN Xue-lei2 |
1. School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences. Jinan 250062 China;
2. Shandong Academy of Occupational Health and Occupational Medicine |
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Abstract Objective To investigate effects of lead and its compounds on biomarkers of oxidative damage and energy metabolism in the blood of battery workers. Methods First,blood lead (BPb) of 590 workers in the lead battery factory were detected, and then according to BPb values,58 workers whose BPb were not more than 120 μg/L were selected as the control group in the non-exposed workers,51 workers with blood lead from 180 μg/L to 220 μg/L were as low-exposure group, 52 workers with blood lead from 280 μg/L to 320ug/L were as the intermediate exposure group and 55 workers with BPb not less than 380 μg/L were as the high exposure group. The level of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) in serum were tested to evaluate the degree of oxidative damage. Activities of succinate dehydrogenase (SDH) in serum and total ATPase in whole blood were detected to evaluate the effects of lead on energy metabolism. Results Compared with the control group, the activity of SOD in low, medium and high exposure groups had significantly declined (P < 0.05); The level of SDH in serum of medium and high exposure groups were higher than that of the control group,which only was seen in male workers(P < 0.05) and was not reflected in female workers(P > 0.05); Whether male or female, the levels of MDA in serum and total ATPase in whole blood did not have statistically significant difference among the four groups (P > 0.05). Conclusion Lead could reduce the activity of SOD and the activity of SOD was a indicator more sensitive than MDA on about assessment of lead oxidative damage; lead bring about the rise about of the activity of SDH in serum to male workers, suggesting that this effect may have gender differences.
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Received: 17 March 2014
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