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| The Experimental Study of the Neutron Irradiation Effects on the Blood TBA and Glucose in Mouse Models |
| CHEN Jian-kui1, PENG Rui-yun2, GAO Ya-bing2, et al |
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Abstract Objective To study the biochemical effects of neutron irradiation on the BALB/C mice including blood total bile acid (TBA) and blood glucose (GLU).Methods All the 728 male mice were randomly assigned into 4 experimental groups and 1 control group.The animals then were irradiated by the 0~5.5 Gy of 90% neutron respectively.Results The serum TBA of 2.5 Gy irradiation group remarkably increased at 6 h after irradiation.On the 14th day after irradiation the TBA decreased gradually.But until the 28th day, the TBA concentration is still higher than that of the control group.The TBA levels in the 3.0~5.5 Gy groups remarkably increased after each dosage irradiation.In the 2.5, 3.0 and 5.5 Gy irradiation groups, the serum glucose levels of mice decreased remarkably at 12 h after irradiation.On the second day, the GLU concentration elevated remarkably in the 5.5 Gy irradiation group.Conclusion The TBA concentration increased after the each dosage of neutron irradiation.The concentration of GLU decreased after small dosage neutron irradiation.Large dosage neutron irradiation can lead to GLU elevated in the blood.
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Received: 07 August 2002
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