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| Effects of Neutron Radiation On Expression of Extracellular Matrix in Renal Tissue |
| PENG Wu-lin, CHEN Tie-he, JIANG Dingwen, et al |
| Naval Medical Research Institute, Shanghai 200433 China |
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Abstract Objective To determine the effect of neutron radiation on expression of extracellular matrix (ECM) in renal tissue.Methods Renal cells separated from rats were exposed at 0.26-1.21 Gy neutron, and were maintained in serum-free medium for a further 48 h.Primary cultures were tested with RIA methods for expression of hyaluronan (HA), laminin (LN) and precollagen-Ⅲ(PCⅢ).Results HA and PCⅢ were reduced remarkably by 0.62 Gy neutron, and were not effected by 0.29 Gy and 1.21 Gy neutron;Irradiated with dose of 0.29 Gy and 1.21 Gy neutron could lead to a remarkable elevation of LN, but 0.62 Gy neutron has no effects to LN.Conclusion Lower dosage of neutron could lead to an altered production of ECM in rat renal tissue.
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Received: 08 September 2005
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