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| The Study on the Immunity Restoring Function of cWPROL in Treating Experimental Radiation Esophagitis |
| SHEN Li, SHAN Bao-en, ZHANG Li, et al |
| Research Center, the fourth hospital of Hebei medical university, Shijiazhuang 050011 China |
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Abstract Objective To study the restorative function of compound white peony root oral liquids (cWPROL) in treating rats' experimental acute radiation-induced esophagitis from the aspect of immunodeficiency.Methods 128 Wistar rats were divided into eight groups.The radiation esophagitis was ieduced by 43 Gy 60Co.Then the rats were treated with medicine in different ways.On every experimental point the absolute number and percentage of T lymphocyte subsets were analyzed by flow cytometry.The changes of the leukocyte in number and differential count were detected by haemocyte counting instrument.IgG and C3 in rats' serum were analyzed by immunological turbidimetry.Results Radiation brought on decrease of experimental rats' leukocyte count, the lymphocyte differential count, absolute count and absolute T lymphocyte subsets in the blood and the content of IgG and C3 with radiation esophagitis.cWPROL could increase the lymphocyte percentage compared that in with the radiated group 2.The preventive (high dose) could increase lymphocyte count while Western medicine decreased rats' leukocyte count, lymphocyte percentage and absolute count (P<0.05).The absolute T lymphocyte subsets in rats' peripheral blood increased in the group infused with cWPROL (high dose)(P<0.001).Compared with the radiated group 2 the absolute T lymphocyte subsets decreased significantly (P<0.001), and the content of complement C3 increased in the group infused with cWPROL (high dose)(P<0.05) but decreased in the group infused with Western medicine (P<0.01).Conclusion cWPROL plays the role of restoring the cytoimmunity and immunity damaged by radiation in rats with radiation esophagitis.
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Received: 15 January 2007
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