|
|
|
| Effects of High Power Microwave Radiation on Expression of POMC Derived Peptides and Heat Shock Protein 70 in Rats |
| LV Shi-jie, JIANG Yan-xia, LU xiao-jing, et al |
| Jilin Medical College, Jilin City 132013 China |
|
|
|
|
Abstract Objective To research the fuction and significance of POMC derived peptides and Hsp 70 by stress damage of high power microwave radiation in rats.Methods 54 male Wistar rats were sacrificed at 6h, 24h and 48h after exposure to high power microwave radiation, using radioimmunity and westernblot to detect β-EP, ACTH and Hsp 70.Results The contents of β-EP in hypophysis decreased significantly (P<0.01), β-EP (P<0.05) and ACTH (P<0.05) in serum increased markedly after 6h radiation;β-EP and ACTH in serum respectively returned to normal level after 24h and 48h.Hsp 70 expression increased significantly 6h and 24h after 100mW/cm2 radiation (P<0.05);24h after 200 mW/cm2 radiation, Hsp 70 expression increased obviously (P<0.05).Conclusion High power microwave radiation can influence thalamencephalon-pituitary nerve-endocrine network function and Hsp70 expression, POMC derived peptides and Hsp participated in the pathophysiologic process of heat stress damage and repair
|
|
Received: 30 April 2007
|
|
|
|
|
|
|
|
|
