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| Study on the Influence of Tumor Cell and Radiation on KH-HL Mice |
| SHEN Xiu, HONG Ge, LIU Pei-xun, et al |
| Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192 China |
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Abstract Objective To observe the susceptibility to tumor cell of KH-HL mice and study the descent of immune function by 137Cs source γ rays to provide theoretical foundations for KM-HL mice use as experimental mice.Methods The mice sarcoma (S180), cervical cancer (U14), and liver cancer (H22)are transplanted on KM-HL mice and the growth of mice bearing tumor is observed, its immune function of KH-HL mice descends when irradiate with 137Cs source γ rays at 6.5Gy, Some immunization indexes such as blood, hematopoietic system, spleen index and thymus index are examined.Results Both the liquid tumor cell and the solid tumor of sarcoma (S180), cervical cancer (U14), and liver cancer (H22)transplants on KM-HL mice grow well.After the irradiation, all of the physiological indexes of KM-HL mice descend comparing with the control group, with statistical significance (P<0.01).Conclusion The inbred line KM-HL mice can be used as experimental model mice in the screening of antitumor and immunological function drugs.
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Received: 02 January 2008
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