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| The Preliminary Study in the Role of Pyrroloquinoline Quinine on the γ-Ray Radiation Protection of Mice |
| QIU Xiu-qin1,2, WU Shi-liang2, LIU Chun-liang2, et al |
| Suzhou Health College、Suzhou Jiangsu 215009 China |
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Abstract Objective To study on the role of PQQ (pyrroloquinoline quinone) in the γ-ray radiation protection of mice.Methods 40 Kunming mice were randomly divided into four groups,namely,non-irradiated group,the simple exposure group,exposure to pre-treatment group,treatment group after irradiation.PQQ mice oral administration was given according to the weight of the daily dose of 2mg/kg,continuous drug delivery for 7 days.60Coγ-ray single irradiation,dose 5 Gy.On the 8th day after irradiation,the mice were killed by cervical dislocation.The collection of serum,liver homogenate was for the determination of biochemical indicators.HE staining of liver slices produced.Results irradiated mouse serum and liver SOD,T-AOC decreased significantly (P<0.05),MDA was significantly higher (P<0.05).Radiation treatment group serum SOD,T-AOC were significantly higher (P<0.05),MDA was significantly reduced (P<0.05);liver SOD content was significantly higher (P<0.05).All irradiated mice liver plate shows liver disorders,edema of liver cells,degeneration and necrosis.Conclusion γ-irradiation in mice induced systemic oxidative stress.Liver is one of the radiation-sensitive organs.PQQ for γ-ray irradiation-induced oxidative stress in mice has some protective effect.Its mechanism:PQQ can directly scavenge free radicals,at the same time,mobilize the whole body irradiated mice scavenging system,particularly the activity of SOD and reduce the generation of free radicals and the free radical content.
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Received: 22 June 2009
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