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| Experimental Study on X-ray Radiation Influence on the Lipid Peroxidation and Free Radicals Metabolic Effects of Body's |
| LI Da-peng1, WANG Yong-qing2, LV Chun-lei2, WANG Feng-jiao1, ZHENG Wen-zhe2 |
| The 88 th Hospital of PLA, Taian 271000 China |
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Abstract Objective To study X-ray radiation effect on the body's lipid peroxidation and metabolic effects of free radicals.Methods 30 Wistar rats without specific pathogens,were randomly and averagly divided into experimental group (A), experimental group (B), the control group (C), the A, B group rats were daily with whole-body-one-time X-ray irradiated for 6 days consecutively, collected,A group radiation dose is 3 Gy, B group radiation dose is 2 Gy, C group receives no radiation. After the completion blood specimens of survival rats were malondialdehyde(MDA) and superoxide dismutase(SOD) and hydrogen peroxide enzyme(CAT) in serum were deteted for 3 group rats for analyse.Results MDA:A group were higher than C group,B group were higher than C group,A group were higher than B group. There were no statistically significant difference between the groups in MDA detection(P> 0.05). SOD:The difference between A and C group was statistically significant(P< 0.05). The difference between A and B group was statistically significant(P< 0.05). The difference between B and C groups has no statistically significance(P> 0.05),while the level of SOD for A group were significantly below than C group,and A group were significantly below than B group; CAT:The difference between A and C group was statistically significant(P< 0.05). The difference between A and B group has no statistical significantce(P< 0.05). The difference between B and C groups has no statistical significantce(P> 0.05),while the level of CAT for A group were significantly below than C group,and A group were significantly below than B group.Conclusion X-ray radiation has significant influence on the SOD and CAT. The significantly reduce the activity of serum SOD and CAT, the antioxidant enzyme of SOD and CAT was anticorrelation with irradiation dose, which can improve the level of serum MDA, and there was no significant influence to the level of MDA.
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Received: 13 October 2015
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