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| Calculation of retention fractions in main source organs following acute americium inhalation based on ICRP biokinetic models |
| CHEN Qianlan, LUO Zhiping, LIU Senlin |
| China Institute of Atomic Energy, Beijing 102413 China |
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Abstract Objective To provide a reference for avoiding the harm to critical target organs following considerable inhalation exposure to the transuranium element americium (Am) as well as post-accident decorporation or other radiation protection measures. Methods We established calculation programs based on the generic criteria for internal radiation emergency preparedness and response in the IAEA Safety Guide No.GSG-2 and current new ICRP biokinetic models and parameters, taking an inhalation of 241Am (activity mean aerodynamic diameter of 5 μm, σ = 2.5) by an adult worker as an example; and determined that the critical target organs were the lung AI region, red bone marrow, and the main source organs leading to acute doses to the critical target organs were the lung AI region, blood, and trabecular bone surface. Results The retention fractions in the main source organs over time after 241Am inhalation were calculated. Conclusion After being absorbed into blood, Am moves quickly to other parts, and Am of different absorption types shows similar early changes in retention fractions in blood: the retention fractions of Am of S, M, and F types in blood peak around 0.03 d, and then halve around 1.7 d. Inhaled Am shows different changes over time in retention fractions in the lung AI region and trabecular bone surface in the early stage: the retention fractions of S- and M-type Am in the lung AI region change little with time, while F-type Am transfers quickly from the lung to blood; In trabecular bone surface, S-type Am increases quickly in the first 7 d, M-type Am gradually increases mainly in the first 2 weeks, and F-type Am increases quickly in the first 2 d.
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Received: 02 September 2023
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[1] International Commission on Radiological Protection. ICRP publication 67. Age-dependent doses to members of the public from intake of radionuclides-part 2 ingestion dose coefficients[R]. Ottawa: ICRP, 1993.
[2] Paquet F, Bailey MR, Leggett RW, et al. ICRP publication 141: occupational intakes of radionuclides: part 4[J]. Ann ICRP, 2019, 48(2/3): 9-501. DOI: 10.1177/0146645319834139
[3] International Atomic Energy Agency. Criteria for use in preparedness and response for a nuclear or radiological emergency[M]. Vienna: IAEA, 2011.
[4] Paquet F, Etherington G, Bailey MR, et al. ICRP publication 130: occupational intakes of radionuclides: part 1[J]. Ann ICRP, 2015, 44(2): 5-188. DOI: 10.1177/0146645315577539
[5] Bolch WE, Jokisch D, Zankl M, et al. ICRP publication 133: the ICRP computational framework for internal dose assessment for reference adults: specific absorbed fractions[J]. Ann ICRP, 2016, 45(2): 5-73. DOI: 10.1177/0146645316661077
[6] ICRP. ICRP publication 100. Human alimentary tract model for radiological protection[R]. Ottawa: ICRP, 2006.
[7] 陈倩兰, 骆志平, 刘森林. 基于ICRP 141号报告的241Am吸入后滞留份额计算及新旧模型异同[J]. 辐射防护,2021,41(1):17-26
Chen QL, Luo ZP, Liu SL. The calculation of the content per intake of 241Am based on ICRP Publication No. 141 and comparison of the new and old models’ results[J]. Radiat Prot, 2021, 41(1): 17-26
[8] 陈倩兰, 骆志平, 刘森林. 基于ICRP 141号报告模型计算吸入241Am后的排泄份额及剂量的对比分析[J]. 辐射防护,2021,41(3):193-200
Chen QL, Luo ZP, Liu SL. The comparison and analysis of excretion fraction after inhalation of 241Am based on ICRP No. 141 biokinetic model[J]. Radiat Prot, 2021, 41(3): 193-200
[9] 陈倩兰, 骆志平, 夏益华. 利用不同呼吸道模型计算239Pu的肺部滞留量结果比较[J]. 中国辐射卫生,2018,27(2):97-101. DOI: 10.13491/j.issn.1004-714X.2018.02.001
Chen QL, Luo ZP, Xia YH. Comparison of calculated lung retention of 239Pu based on different human respiratory tract models[J]. Chin J Radiol Health, 2018, 27(2): 97-101. DOI: 10.13491/j.issn.1004-714X.2018.02.001
[10] 周文华, 尹晶晶, 高洁, 等. 体内铀毒性及其新型促排剂研究进展[J]. 中国辐射卫生,2022,31(3):379-385. DOI: 10.13491/j.issn.1004-714X.2022.03.023
Zhou WH, Yin JJ, Gao J, et al. Research advances in toxicity of uranium in vivo and its new chelators[J]. Chin J Radiol Health, 2022, 31(3): 379-385. DOI: 10.13491/j.issn.1004-714X.2022.03.023
[11] Bruenger FW, Stevens W, Stover BJ. Americium-241 in the blood in vivo and in vitro observations[J]. Radiat Res, 1969, 37(2): 349-360. DOI: 10.2307/3572738
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