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| Advances in the study of biomarkers of early uranium-induced kidney injury |
| SHI Xinhua1, ZHAO Lianfeng2, DOU Yichang1, GU Xiaona2, ZHAN Jingming2, XUE Xiangming2 |
1. CNNC North Nuclear Fuel Element Co., Ltd, Baotou 014000 China;
2. China Institute for Radiation Protection, Taiyuan 030006 China |
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Abstract With the rapid development of the nuclear industry, the uranium-exposed population is rapidly expanding. Kidney injury is a major health concern for uranium-exposed population because uranium is initially retained in the kidneys and induces chemical toxicity. However, the commonly used clinical markers of kidney injury usually show significant changes in the late stages of such damage, making it difficult to monitor the occupational health of uranium-exposed population. In recent years, a number of biomarkers that can reflect early kidney injury caused by uranium have been identified and investigated by enzyme-linked immunosorbent assay and protein blotting. This article will review the studies in this area, with the aim of providing a basis for the diagnosis and understanding the development and prognosis of uranium-induced kidney injury.
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Received: 25 October 2022
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