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| Research progress of ceria nanoparticles in the field of radiation |
| YANG Luxun1, YIN Yaru1, LUO Shenglin1, LIU Jing1, LU Binghui1, YANG Zhangyou2, LI Rong1 |
1. Institute of Compound Injuries, Department of Military Preventive Medicine, Army Military Medical University, State Key Laboratory of Combined Wounds and Burns, Key Laboratory of Nanomedicine of the PLA, Chongqing 400038 China;
2. Department of Pharmacy, Chongqing Medical University, Chongqing 400030 China |
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Abstract With the rapid development of nuclear technology in the fields of industry and medicine, the possibility of people suffering from radiation damage has also increased. Radiation injury prevention and treatment drugs are the most effective and direct means for the treatment and protection of radiation injury, but the current radiation injury prevention and treatment drugs have limited effects. Due to the unique valence structure of cerium nanomaterials, it has a variety of enzymatic simulation activities and reproducibility. It shows superior oxidation resistance, powerful free radical scavenging function, and can protect cells from radiation damage. It can be used as an ideal it is a radioprotective agent, and is used in a variety of biological fields. A review of relevant literature shows that the antioxidant properties, high SOD mimicking activity, free radical scavenging ability and radiation resistance of ceria nanoparticles are derived from the mutual conversion of Ce3+/Ce4+ and the formation of oxygen vacancies. This article mainly introduces the basis of anti-radiation activity of ceria nanoparticles, radiation protection effects and the research progress of radiotherapy sensitization, and provides theoretical basis and reference for ceria nanoparticles in the field of radiation direction.
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Received: 04 May 2021
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