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| Radioprotective Effect of Polysaccharides Isolated from Tremella Fuciformis in Mice |
| HAN Ying, SHEN Xiu, XU Wen-qing, YANG Fu-jun, XUE Dan, ZHANG Yu-jie, LI Ji-yang |
| Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192 China |
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Abstract Objective To investigate the radioprotective effect of polysaccharides isolated from Tremella fuciformis in mice. Methods A 30-day survival assay and the hematological parameters of the peripheral blood were adopted to explore radioprotective effect. Results Mice were treated with polysaccharides once per day for three consecutive days before 8Gy gamma irradiation. The treatment groups receiving 18, 54 and 72 mg/kg body weight (b. w.) of polysaccharides showed 40%~50% survival post-irradiation. The 30-day survival and the average number of survival days were high compared to that of the radiated group. The hematological parameters of the peripheral blood indicated that polysaccharides, when administered at doses of 72 mg/kg b. w., significantly restored hemoglobin, white blood cell counts and red blood cell counts by the 14th day and 18th day. Conclusion Polysaccharides isolated from Tremella fuciformis could reduce the injury by radiation in mice.
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Received: 27 December 2011
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