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| Clinic Analysis of Bone Mineral Density and its Related Factors in Patients with Type 2 Diabetes |
| YUAN Hang, ZHU Bao, WANG Jun-chao, XIAO Yi-chun |
| Department of Nuclear Medicine, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214023 China |
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Abstract Objective To investigate the related factors for osteoporosis in patients with type 2 diabetes mellitus. Methods The bone mineral density (BMD) at lumbar vertebrae (L1-4),left femur neck, greater trochanter of femur and left Shaft of femur were measured by dual energy X-ray absorptiometry in 120 patients with type 2 diabetes mellitus. The patients were divided into three groups:normal group, osteopenia group and osteoporosis group. The correlations between BMD and age,course of disease, body mass index (BMI) and serumal indicators were analyzed by multivariate regression analysis. Results there were siginificantly statistical differences in age, course of disease,BMI,ALP,SNTX and 25-VitD between normal and osteoporosis group (P < 0.05), while there are differences only in course of disease between normal and osteopenia group. Logistic regression analysis showed that BMD of all those locum had independent correlation with age,BMI and 25-VitD, but also with course of disease except lumbar vertebrae. There was an negative correlation between ALP and BMD of all other locums except left Shaft of femur. Furthermore, SCTX and SNTX had an negative correlation with lumbar vertebrae and left Shaft of femur respectively. Conclusion In patients with type 2 diabetes mellitus,age, course of disease and low BMI are risk factors for osteoporosis, and it may be help ful to anticipate osteoporosis happening in future by detecting serumal 25-VitD,ALP,SNTX and SCTX.
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Received: 17 June 2014
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