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| Morphometric study on late effect of Ⅰ131、132Ⅰ on rat thyroid gland (Study on gland level) |
| Cao Zhenshan, et al |
| Institute of Radiation Medicine, Beijing 100850 |
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Abstract Changes are reported here in three dimensional stereologic parameters of rat thyroid glands at 20 months after injury induced by Ⅰ131、132Ⅰ with image analysis and morphometric methods.The results showed that colloid and follicular volume density and surface area density of various dosage groups were all significautly smaller than those of the control (0 dose) group, and were dose-dependent (P<0.01).However the volume density of interstitial tissue was negatively dose-dependent (P<0.01).The colloid and follicular specific surface area of various dosage groups were all significantly larger than those of the control group (P<0.01), indicating colloid and follicular volumes were decreased.It is confirmed that by the semi-increase or semi-reduction dose D50 calculated from the regression equation of volume density, surface area density, and absorbed dose that the relative biological effectiveness (RBE) of Ⅰ132 was 10~25-fold of Ⅰ131, i.e., with same irradiation dose, the extent of injury induced by Ⅰ132 would be 10~25 times larger than that by Ⅰ131.
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Received: 03 December 1996
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