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| The change of the pathology and anti-oxidase in the tumor-bearing mice liver with low dose irradiation |
| Feng Leping, et al |
| Jilin Provence Cancer Research Institute, Changchun 130012 |
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Abstract Objective: To understand the change of tumor-bearing mice malignant tissue pathology and liver antioxidase. Method: Using enzymological and pathological analysis to study the active of SOD、GSH-Px, content of LPO in liver as well as the change of carcinoma tissue. Results: The study shown that the active of antioxidose in liver were aroused for the tummor-bearing mice whosewhole bady pre-exposed to 50 mGg low dose X-ray. The level of MDA was reduced. In the condition of large dose X-ray local irradiation radiotherapy increased gradually after low dose irradiation, the active of the SOD and GSH-Px showed a tendency of increase more than that of contrast groups. At that time the content of the MDA reached that of contrast group. Under optical microscope many lgmphocytes were found to be invoded by the neighbovring malignant tissnes, capillaries, to be dilated and hyperemia occurred. Conclusion: Low dose irradiation can stimulate the active of antioxi dase system in liver of tumor-bearing mice and enhance it to high; Under the condition of large dose radiotherapy SOD、GSH-Px can be induced by the pre-exposed 50mGy low dose irradiation, on the contrary, LPO be reduced; Low dose irradiation can promote the effect of radiotherapy and play a role as radioprotect effect on the normal physiological function.
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Received: 25 July 1999
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