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| Research on the Main Factors of Dose Estimation Influenced by Autoradiography |
| DAI Guang-fu, WANG Ming-xi, KOU Ming-ying, et al |
| Institute of Radiotion Medicine, Chinese Academy of Medical Scieces and Peking Union Medical College, Tianjin 300192, China |
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Abstract Objective In most situations, the spatial locations of radiopharmaceuticals are not uniform, so that in order to estimate the dose to cells and cell nuclei is necessary.Methods Autoradio-graphy (ARG) is a method to obtain the precise spatial information of the (radiolabels, relative to the tissue histology.In the study, the microscopic locations of this) radioactive substance in the liver of mice were investigated through microscopic frozen section ARG, and a mathematical model was developed, which can be conveniently used to microdosimetry, such as estimations of the doses received by the cell nuclei in rat liver after injection of 99mTc-MIBI via tail veins in this test.Results A comparison of the radiation dose rate estimates was conducted between the cellular dosimetry model and MIRD, revealing significant differences.Conclusion ARG was proved to be a useful approach to provide detailed spatial and dosimetric information on radiopharmaceuticals within organs so that we can evaluate precisely the effectiveness of radiotherapy and radiotoxicity and microscopic radiation-effect in nuclear medicine.In this study the influence factors of dose estimation are detail analysed and discussed.
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Received: 19 September 2000
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