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| Clinical Treatment of Combined Small Cell Esophageal Cancer |
| JIANG Chao, ZHANG Peng-cheng, WANG Huan-huan, MENG Mao-bin, YUAN Zhi-yong |
| Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060 China |
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Abstract Objective To explore the clinical features, prognostic factors, and role of surgery, radiotherapy and chemotherapy in combined small cell esophageal cancer(C-SCEC). Methods We retrospectively analyzed the clinical data of 32 Patients with C-SCEC from the Cancer Hospital of Tianjin Medical University between January 1989 and April 2012. The Kaplan-Meier method was used to estimate survival, and the log-rank test was used for univariate prognostic analysis. Results A total of 29 patients (90.6%) participated in follow-up visits. The overall survival of the patients ranged between 4.3 and 86.5 months with a median of 13.5 months. The one-、two- and three-year survival rates were 55.3%、31.6%、15.8%, respectively. The univariate analysis showed that TNM stage (P=0.01), N-stage (P=0.01) and M-status (P=0.02) were associated with OS; the number of chemotherapy cycles (≥ 4) and chemotherapy after location therapy (surgery or radiotherapy) nonsignificantly improved the OS in C-SCEC (P=0.147 and P=0.086). Conclusion C-SCEC is major in Limited-stage, and multimodality therapy is recommended. TNM stage, N-stage and M-status are prognostic factors. Surgery combined with radiotherapy and chemotherapy may improve the OS.
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Received: 28 December 2013
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