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| Radioprotective Effects of KGF and Its Combination with G-CSF on Important Organ in 137Cs γ-ray 5Gy Irradiated Mice |
| ZHANG Peng-cheng1, CAO Yong-zhen1, YU Cheng-cheng2, JIANG En-hai2 |
1. Department of Radiation Oncology, General Hospital of Tianjin Medical University, Tianjin 300052 China;
2. Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College |
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Abstract Objective To study the protective effects of keratinocyte growth factor (KGF) and granulocyte colonystimulating factor (G-CSF) on hematopoietic system and important organs in irradiated mice. Methods 70 6-to 8-week old C57BL/6 mice were chosen as the objects on of study. They were randomly divided into 5 groups:the control group, irradiation group, KGF group, G-CSF group and the KGF plus G-CSF group, administered respectively after the 137Cs-gamma ray whole body irradiation. By detecting the body weight, organ index, organ SOD activity, MDA content, peripheral blood (WBC, RBC, Hb, PLT), the effect of KGF and G-CSF on irradiated mice blood and major organs were analyzed. Results After irradiation, the weight of KGF group and G-CSF group picked up more clearly; Compared with G-CSF group, there was statistically significant difference in lung index combined group (P < 0.05); Content index of peripheral blood RBC, Hb, PLT, combined group was higher than that of the other group; liver, heart SOD activity in G-CSF group is higher than that of KGF group and combined group, lung SOD activity in KGF group is higher than that of G-CSF group and combined group. Conclusion This study shows that of the mice hematopoietic system restoration in the combined is better than that of the other groups:G-CSF is more effective for the liver and heart antioxidant capacity; KGF is more effective for pulmonary antioxidant capacity.
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Received: 23 October 2013
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WANG Qing-rong, HE Ying, SHEN Xian-rong, JIANG Ding-wen, LI Ke-xian, LIU Yu-ming, QIAN Tian-tian, CHEN Wei, WANG Yan. Radioprotective Effects of Sodium Borocaptate on Acute Radiation-Injured Mice[J]. , 2014, 23(1): 47-49. |
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