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| Effects of Low Dose Radiation on Antioxidant Enzymes after Radiotherapy of Tumor-bearing Mice |
| LI Jin, GAO Gang, WANG Qin, et al |
| Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China |
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Abstract Objective To search for effects of low dose radiation on the activities of antioxidant enzymes after radiotherapy of tumor-bearing mice.Methods Superoxide dismutase (SOD), glutathione-S-transferase (GST) and catalase (CAT) were all determined by chemical colorimetry.Results Low dose radiation increase the activities of antioxidant enzymes superoxide dismutase (SOD), glutathione-S-transferase (GST) and catalase (CAT) in serum of tumor-bearing mice more markedly than those in the unirradiated controls.The activities of antioxidant enzymes SOD, GST, CAT in serum of tumor-bearing mice (d5, d3) irradiated with 5cGy 6h before 2.0Gy radiation are obviously higher than those of the group (c3, c5) given with radiotherapy only.Conclusion The increase in the activities of antioxidant enzymes in serum of tumor-bearing mice triggered by low dose radiation could partly contribute to the protective mechanism.
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Received: 28 September 2004
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