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| Variation of Cytokines of lung macrophage in mice with GVHD |
| HOU Le-zhi1, RUI Qing-long1, WANG Huai-ming1, et al |
| The Central Hospital of Zaozhuang Mining Bureau, Zaozhuang 277011 China |
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Abstract Objective To detect the modulation of production of some cytokines of lung macrophage in mice after allogeneic bone marrow transplantation.Methods IL-1β and TNFαlevels in macrophage culture supernatants were estimated by ELISA method.Results The extent of mixed lymphocyte reaction in vivo was higher in allogeneic but not in syngeneic BMT group.The peripheral blood WBC count and bone marrow CFU-GM colonies in allogeneic BMT group were lower than that in the syngeneic group.The secretion level of IL-1β or TNFα was higher in the allogeneic group than that in syngeneic group.Conclusion The results indicated that IL-1β and TNFα secretion play an important role in the GVHD reaction.
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Received: 19 June 2006
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