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| Clinical Observation of Oral and Retention Enema with Smecta in the Treatment of Acute Radiation Enteritis |
| CHEN Feng1, LI Quan-fu1, JIN Gao-wa1, ZHANG Hao-yang2 |
1. Department of Oncology Erdos City Center Hospital, Erdos 017000 China;
2. School of Public Health, Sun Yat-sen University Guang Zhou Guang Dong |
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Abstract Objective To observe the efficacy of oral and retention enema with Smecta in the treatment of acute radiation enteritis.Methods A total of 57 patients with cervical cancer were randomized into oral group (n=30) and retention enema group with smecta (n=27).All the patients were treated with three- dimensional and intensity modulated radiotherapy in combination with cisplatin.The efficient and the mean duration of different levels of radiation enteritis treatment were compared.Results The efficiency of retention was significantly higher than that of the oral group in level 2 and above radiation enteritis (P<0.05).The treatment duration of retention group significantly was shorter than that of the oral group in all patients with radiation enteritis (P<0.05).Conclusion The treatment duration was shortened and efficiency was increased with retention enema with Smecta. Retention enema is recommended in patients with level 2 radiation enteritis and smecta oral administration may be combined.
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Received: 11 August 2016
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[1] 殷蔚伯,余子豪,徐国镇,等.肿瘤放射治疗学[M].北京:中国协和医科大学出版社, 2007:864.
[2] 敖睿,卢铀.放射性肠炎发生机理最新研究进展[J].实用医院临床杂志,2009,6(2):112-114.
[3] 李富荣,孙涛.放射性肠炎发生机制的研究进展[J].医学综述,2011,17(2):257.
[4] Wither HR.Treatment induced accelerate human tumor growth[J],Seminars in Radiat Oncol,1993,3(1):135-141.
[5] Membrive Conejo 1,Reig Castillejo A,Rodriguez de Dios N,et al.Prevention of acute radiation entetitis:efficacy and tolerance of glutamine[J].Clin "fransl Onc:o1,2011,13(10):760-763.
[6] 张森,陈道帧,复方谷氨酰胺联合思密达治疗急性放射性直肠炎疗效观察[J].药物与临床,2012,2(5):72-74.
[7] 刘桂伟,马小群,任维聃,等.复方中药同步放化疗治疗局部晚期直肠癌的临床研究[J].现代肿瘤医学,2015,23(10):1406-1409.
[8] 董晶,赵西侠,舒瑾.中药保留灌肠预防宫颈癌放射性直肠炎的临床观察[J].现代肿瘤医学,2012,20(7):1421-1423.
[9] 赵维勇,张丽珍,赵滑峰,等.复方谷氨酰胺胶囊防治急性放射性直肠炎临床研究[J].现代肿瘤医学, 2013, 21(4):808-810.
[10] 丁秋娥,徐西伟,王思阳,等.思密达-白介素-11混合液保留灌肠治疗急性放射性直肠炎的临床观察[J].中国实用医药,2012,7(21);12-13.
[11] Fiorino C, Alongi F, Perna L, et al. Dose-Volume Relationships for Acute Bowel Toxicity in Patients Treated With Pelvic Nodal Irradiation for Prostate Cancer[J]. International Journal of Radiation Oncology Biology Physics, 2009, 75(1):29-35.
[12] Simpson D R, Song W Y, Moiseenko V, et al. Normal Tissue Complication Probability Analysis of Acute Gastrointestinal Toxicity in Cervical Cancer Patients Undergoing Intensity Modulated Radiation Therapy and Concurrent Cisplatin[J]. International Journal of Radiation Oncology Biology Physics, 2012, 83(1):81-86. |
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