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| Changes of Serum Lipid for Patients with Subclinical Hypothyroidism Induced by Post-radiotherapy Nasopharyngeal Carcinoma |
| SHAO Qian, ZHAO Bao-hua, LIANG Chao-qian, et al |
| Department of Radiation Oncology, Shandong Tumor Hospital and Institute, Jinan 250117 China |
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Abstract Objective To study the changes of serum lipid of pre-and post-treatment by Levothyroxine (LT4) for patients with subclinical hypothyroidism (SHT) induced by post-radiotherapy nasopharyngeal carcinoma (NPC).Methods From Nov.1998 to Nov.2002, 76 NPC pathologically confirmed patients were treated by radiotherapy.The total dose of thyroid was 45Gy~60Gy and the median dose was 50Gy.There were 40 patients with normal thyroid function (NC group) and 36 patients with subclinical hypothyroidism (SHT group).The SHT patients received LT4 treatment from 25μg/day with the does gradually increased till thyrotropin (TSH) was normal.The serum levels of TSH, free thyroxine (FT4), free triiodothyronine (FT3), total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) in NC group and SHT group was measured and compared before and after LT4 treatment.Results The serum levels of TSH、FT3、FT4、TC、TG、HDL-C、LDL-C in pre-and post-treatment SHT group and NC group were significantly different between those in the pre-and post-treatment SHT group was measured ana compared, and pre-treatment SHT group and NC group except HDL-C (P<0.001 or 0.05).Conclusions Radiotherapy on NPC patients can induce SHT, and LT4 treatment for SHT patients can ameliorates the function of thyroid and metabolism of serum lipid.
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Received: 31 August 2006
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